Atopic and nonatopic eczema in adolescence: is there a difference?
Atopic and nonatopic eczema in adolescence: is there a difference?
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DOI：
10.1111/bjd.13901
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发表时间：
2015-10-01
影响因子：
10.3
通讯作者：
Wahlgren, C. -F.
中科院分区：
文献类型：
--
作者：
Johansson, E. K.;Ballardini, N.;Wahlgren, C. -F.
背景有有限的信息，特应性湿疹（AE）和非AE在teenages.Objectives的临床表现描述的特点，青少年湿疹在一般人群中，并确定潜在的差异AE和非AE在teenagers.Methods总的来说，3108名青少年包括从人口为基础的BAMSE队列和2529这些青少年提供血液样本进行特异性IgE分析。在16岁时，青少年回答问卷调查有关的症状湿疹，哮喘和鼻炎的前一year.Results湿疹在青春期的患病率为9.6%（n = 297）。湿疹的女孩多于男孩（12.5%比6.5%; P < 0.001）。发病年龄通常在2岁以内（48.8%），但在青春期发病也很常见（25.6%）。72.7%的病例为轻度，16.8%为中度，10.4%为重度。身体褶皱最常见的影响（73.4%）。超过一半的青少年湿疹患者有AE（59%）。AE组青少年湿疹症状重、慢性化程度高。AE中婴儿期发作最常见，非AE中青春期发作最常见。青少年期AE与非AE发生的部位和季节差异无显著性。结论青少年中AE较非AE多见。超过四分之一的患有湿疹的青少年患有中度至重度疾病。在青春期发作很常见，尤其是非AE。青春期AE比非AE发作更早，更慢性，更严重。
Background There is limited information on clinical manifestations of atopic eczema (AE) and non-AE in teenagers.Objectives To describe the characteristics of adolescent eczema in the general population and to identify potential differences between AE and non-AE in teenagers.Methods Overall, 3108 teenagers were included from the population-based BAMSE cohort and 2529 of these teenagers provided blood samples for analysis of specific IgE. At age 16 years, the teenagers answered questionnaires regarding the symptoms of eczema, asthma and rhinitis for the previous year.Results The prevalence of eczema in adolescence was 9.6% (n = 297). More girls than boys had eczema (12.5% vs. 6.5%; P < 0.001). The age at onset was usually within the first 2 years of life (48.8%), but onset in adolescence was also common (25.6%). Eczema was mild in 72.7% of cases, moderate in 16.8% and severe in 10.4%. Body folds were most frequently affected (73.4%). More than half of the teenagers with eczema had AE (59%). The teenagers with AE had more severe and more chronic eczema. Onset in infancy was most common in AE and onset in adolescence was most common in non-AE. There were no major differences in location or seasonal variance between AE and non-AE in adolescence.Conclusions AE is more common than non-AE among teenagers. More than one in four teenagers with eczema has moderate-to-severe disease. Onset in adolescence is common, especially for non-AE. AE in adolescence has an earlier onset and is more chronic and more severe than non-AE.