The amino-terminus and membrane-spanning domains of LMP-1 inhibit cell proliferation
The amino-terminus and membrane-spanning domains of LMP-1 inhibit cell proliferation
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DOI：
10.1038/sj.onc.1203365
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发表时间：
2000-03-09
期刊：
影响因子：
8
通讯作者：
Sugden, B
中科院分区：
文献类型：
--
作者：
Kaykas, A;Sugden, B
EBV的LMP-1癌蛋白是维持感染的B细胞增殖所必需的，并且与CD 40、TNF-R1和相关受体共享若干特征。该家族的成员可以结合TRAF和TRADD分子并激活NF-κ B和AP-1，LMP-1也可以。虽然CD 40和TNF-R1依赖于结合其配体用于其信号传导，但LMP-1显然不是。我们已经发现LMP-1可以作为细胞增殖的调控因子，从而限制其自身的活性，其增殖抑制不是通过凋亡介导的，而是导致四种测试的细胞系中的细胞停滞。LMP-I的结构部分（其氨基末端和多个跨膜片段）可单独介导其细胞抑制活性，这使其与CD 40和TNF-R1不同。
The LMP-I oncoprotein of EBV is required to maintain proliferation of infected B-cells and shares several features with CD40, TNF-R1, and related receptors, Members of this family can bind TRAF and TRADD molecules and activate NF-kappa B and AP-I, as can LMP-1, While CD40 and TNF-R1 are dependent on binding their ligands for their signaling, LMP-1 apparently is not, We have found that LMP-1 can act as a governor of cell proliferation and thereby limit its own activities, its inhibition of proliferation is not mediated by apoptosis but results in cytostasis in four cell lines tested. The structural moiety of LMP-I that distinguishes it from CD40 and TNF-R1, its amino-terminus and multiple membrane spanning segments, alone can mediate its cytostatic activity.