Detection of M. tuberculosis DNA in TB contacts' PBMC does not associate with blood RNA signatures for incipient tuberculosis
Detection of M. tuberculosis DNA in TB contacts' PBMC does not associate with blood RNA signatures for incipient tuberculosis
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结核病接触者 PBMC 中结核分枝杆菌 DNA 的检测与早期结核病的血液 RNA 特征无关
DOI：
10.1101/2023.09.26.23296131
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Rosenheim J
中科院分区：
文献类型：
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作者：
Rosenheim J
人们认为，人类接触结核分枝杆菌 (Mtb) 会导致一系列结果，包括细菌清除、静止 Mtb 感染、初期结核病、亚临床结核病和活动性结核病 [1]。初期结核病——定义为在临床表现为活动性疾病之前的早期疾病的长期无症状期[2]——可以通过检测血液中宿主基因表达特征来与静止结核分枝杆菌感染区分开来，其存在与进展为活动性结核病的风险增加相关[3]。我们和其他人之前曾报道过在胸片正常的无症状结核病暴露成人的 CD34 阳性外周血单核细胞 (PBMC) 中检测到 Mtb DNA [4-6]。
ExtractHuman exposure toMycobacterium tuberculosis(Mtb) is thought to result in a spectrum of outcomes including bacillary clearance, quiescent Mtb infection, incipient tuberculosis, subclinical tuberculosis and active tuberculosis [1]. Incipient tuberculosis - defined as a prolonged asymptomatic phase of early disease preceding clinical presentation as active disease [2] – may be distinguished from quiescent Mtb infection by detection of host gene expression signatures in blood, whose presence associates with increased risk of progression to active TB [3]. We and others have previously reported detection of Mtb DNA in CD34-positive peripheral blood mononuclear cells (PBMC) of asymptomatic TB-exposed adults with normal chest radiographs [4–6].