Anxiety-like behaviors and hippocampal nNOS in response to diet-induced obesity combined with exercise
Anxiety-like behaviors and hippocampal nNOS in response to diet-induced obesity combined with exercise
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DOI：
10.1007/s12576-019-00686-5
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发表时间：
2019-05
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通讯作者：
Yuki Tomiga;Saki Yoshimura;Song-Gyu Ra;Yuri Takahashi;Rina Goto;Ikumi Kugimoto;Y. Uehara;K. Kawanaka
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文献类型：
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作者：
Yuki Tomiga;Saki Yoshimura;Song-Gyu Ra;Yuri Takahashi;Rina Goto;Ikumi Kugimoto;Y. Uehara;K. Kawanaka
高脂肪饮食（HFD）和超重状态可诱导海马功能障碍，导致抑郁和焦虑。锻炼对情绪行为有有益的影响。我们之前报道过，运动训练可以缓解hfd诱导的海马神经元一氧化氮合酶（nNOS）的过度表达，而nNOS是焦虑的关键调节因子。在这里，我们研究了HFD联合运动对焦虑样行为和海马nNOS表达的反应。小鼠被分配到标准饮食组、HFD组或HFD加运动组，为期12周。我们发现，在HFD治疗的最后6周，运动改善了HFD诱导的12周排便，并伴有过量nNOS表达的恢复。然而，在高架加迷宫中，焦虑指标没有变化。仅仅锻炼一周后，这些效果就不明显了。总之，根据我们的测量之一（排便），6周的运动训练减少了hfd相关的焦虑，并逆转了海马nNOS/NO通路的变化。
A high-fat diet (HFD) and overweight status can induce hippocampal dysfunction, leading to depression and anxiety. Exercise has beneficial effects on emotional behaviors. We previously reported that exercise training rescues HFD-induced excess hippocampal neuronal nitric oxide synthase (nNOS) expression, which is a key regulator of anxiety. Here, we investigated anxiety-like behaviors and hippocampal nNOS expression in response to HFD combined with exercise. Mice were assigned to standard diet, HFD, or HFD with exercise groups for 12 weeks. We found that exercise during the final 6 weeks of the HFD regime improved 12 weeks of HFD-induced defecation, accompanied by rescue of excess nNOS expression. However, anxiety indicators in the elevated plus maze were unchanged. These effects were not apparent after only 1 week of exercise. In conclusion, 6 weeks of exercise training reduced HFD-related anxiety according to one of our measures (defecation), and reversed changes in the hippocampal nNOS/NO pathway.