SNARE proteins: zip codes in vesicle targeting?
SNARE proteins: zip codes in vesicle targeting?
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SNARE蛋白：囊泡靶向中的邮政编码？
DOI：
10.1042/bcj20210719
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发表时间：
2022-02-11
期刊：
影响因子：
--
通讯作者：
Jahn R
中科院分区：
文献类型：
--
作者：
Koike S;Jahn R
真核细胞中的膜运输是由运输囊泡介导的，这些囊泡从前体囊室萌发并被运送到它们的目的囊室，在那里它们停靠并融合。为了到达细胞内的目的地，运输囊泡含有靶向信号，如Rab gtpase和多磷酸肌苷，这些信号被细胞质中的系聚因子识别，并将囊泡与其各自的目的地室连接起来。最后一步，膜融合，由SNARE蛋白介导。SNAREs通过多种相互作用与目标信号和系留因子相连接。然而，SNAREs是否仅在靶向和系留的下游起作用，或者它们是否也参与调节靶向特异性，仍然存在争议。在这里，我们回顾了证据并讨论了支持SNARE蛋白在囊泡运输中作为靶向信号的作用的最新数据。
Membrane traffic in eukaryotic cells is mediated by transport vesicles that bud from a precursor compartment and are transported to their destination compartment where they dock and fuse. To reach their intracellular destination, transport vesicles contain targeting signals such as Rab GTPases and polyphosphoinositides that are recognized by tethering factors in the cytoplasm and that connect the vesicles with their respective destination compartment. The final step, membrane fusion, is mediated by SNARE proteins. SNAREs are connected to targeting signals and tethering factors by multiple interactions. However, it is still debated whether SNAREs only function downstream of targeting and tethering or whether they also participate in regulating targeting specificity. Here, we review the evidence and discuss recent data supporting a role of SNARE proteins as targeting signals in vesicle traffic.