An update on community-associated MRSA virulence
An update on community-associated MRSA virulence
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DOI：
10.1016/j.coph.2009.07.009
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发表时间：
2009-10-01
影响因子：
4
通讯作者：
DeLeo, Frank R.
中科院分区：
文献类型：
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作者：
Kobayashi, Scott D.;DeLeo, Frank R.
金黄色葡萄球菌是世界范围内的主要健康问题，也是美国细菌感染的主要原因。从历史上看，金黄色葡萄球菌作为一种人类病原体的成功是由其强烈的抗药性倾向推动的，而且多重耐药菌株在医院是地方性的。然而，近年来细菌感染史上最引人注目的发展之一是社区相关耐甲氧西林金黄色葡萄球菌(CA-MRSA)的迅速出现。自20世纪90年代首次报道以来，CA-MRSA已在全球范围内出现，并在美国流行。这种病原体的特点是能够迅速传播，并在其他健康的人中造成感染。本文综述了近年来对CA-MRSA毒力增强特性的研究进展，重点介绍了Panton-瓦伦丁杀白素、α-溶血素和新近发现的a型苯酚可溶性调节素。
Staphylococcus aureus is a major health problem worldwide and the leading cause of bacterial infections in the United States. Historically, the success of S. aureus as a human pathogen has been facilitated by a strong propensity to develop antibiotic resistance and multidrug resistant strains are endemic in hospitals. However, one of the most striking developments in recent bacterial infectious disease history was the rapid emergence of community-associated methicillin-resistant S. aureus (CA-MRSA). First reported in the 1990s, CA-MRSA has since emerged worldwide and is epidemic in the United States. The pathogen is characterized by its ability to spread rapidly and cause infections in otherwise healthy individuals. This review focuses on current progress toward understanding the enhanced virulence properties of CA-MRSA, with an emphasis on Panton-Valentine leukocidin, alpha-hemolysin, and the recently discovered a-type phenol-soluble modulins.