Aortic pulse wave velocity predicts cardiovascular mortality in subjects >70 years of age
Aortic pulse wave velocity predicts cardiovascular mortality in subjects >70 years of age
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DOI：
10.1161/hq1201.100226
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发表时间：
2001-12-01
影响因子：
8.7
通讯作者：
Safar, ME
中科院分区：
文献类型：
--
作者：
Meaume, S;Benetos, A;Safar, ME
主动脉脉搏波速度（PWV）是原发性高血压和终末期肾病患者心血管死亡率的重要独立预测因子。它对70至100岁受试者心血管风险的贡献从未得到过测试。在巴黎郊区的3个老年病科对141名受试者（平均± SD年龄，87.1 ± 6.6岁）进行了队列研究。与血压计血压测量一起，使用经验证的自动装置测量主动脉PWV。在30个月的随访中，56名患者死亡（27名死于心血管事件）。Logistic回归分析显示，年龄（P=0.005）和自主性丧失（P=0.01）是总死亡率的最佳预测因子。对于心血管死亡率，主动脉PWV是主要的风险预测因子（P=0.016）。优势比为1.19（95%置信区间，1.03至1.37）。抗高血压药物治疗与血压，包括收缩压和脉压。没有附加作用。在70 - 100岁的受试者中，主动脉PWV是心血管死亡的强有力的独立预测因子，而收缩压或脉压不是。这一预期结果需要在干预试验中得到证实。
Aortic pulse wave velocity (PWV) is a significant and independent predictor of cardiovascular mortality in subjects with essential hypertension and in patients with end-stage renal disease. Its contribution to cardiovascular risk in subjects 70 to 100 years old has never been tested. A cohort of 141 subjects (mean +/- SD age, 87.1 +/-6.6 years) was studied in 3 geriatrics departments in a Paris suburb. Together with sphygmomanometric blood pressure measurements, aortic PWV was measured with a validated automatic device. During the 30-month follow-up, 56 patients died (27 from cardiovascular events). Logistic regressions indicated that age (P=0.005) and a loss of autonomy (P=0.01) were the best predictors of overall mortality. For cardiovascular mortality, aortic PWV was the major risk predictor (P=0.016). The odds ratio was 1.19 (95% confidence interval, 1.03 to 1.37). Antihypertensive drug treatment and blood pressure, including systolic and pulse pressure. had no additive role. In subjects 70 to 100 years old, aortic PWV is a strong, independent predictor of cardiovascular death, whereas systolic or pulse pressure was not. This prospective result will need to be confirmed in an intervention trial.