Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans
Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans
复制标题
DOI：
10.1038/s41467-019-11444-x
复制
发表时间：
2019-08-08
影响因子：
16.6
通讯作者：
Knight, Robert T.
中科院分区：
文献类型：
--
作者：
Helfrich, Randolph F.;Lendner, Janna D.;Knight, Robert T.
记忆是如何从短期存储转移到长期存储的？系统水平的记忆巩固被认为依赖于皮质慢波、丘脑-皮质睡眠纺锤波和海马涟漪振荡的协调相互作用。然而，目前还不清楚这些基本睡眠振荡的选择性相互作用是如何组织的，以支持信息的重新激活和转移。在这里，使用人类颅内记录，我们证明了前额叶皮层在非快速眼动（NREM）睡眠期间组织涟漪介导的信息传递中起着关键作用。我们揭示了前额叶慢波和纺锤波振荡之间的时间精确的耦合形式，它积极地决定了大脑皮层的对话和信息传递。我们的研究结果表明，在人类睡眠的大脑模型中，快速的双向互动，触发的前额叶皮层，介导海马激活，以最佳的时间随后的信息传递到新皮层在NREM睡眠。
How are memories transferred from short-term to long-term storage? Systems-level memory consolidation is thought to be dependent on the coordinated interplay of cortical slow waves, thalamo-cortical sleep spindles and hippocampal ripple oscillations. However, it is currently unclear how the selective interaction of these cardinal sleep oscillations is organized to support information reactivation and transfer. Here, using human intracranial recordings, we demonstrate that the prefrontal cortex plays a key role in organizing the ripple-mediated information transfer during non-rapid eye movement (NREM) sleep. We reveal a temporally precise form of coupling between prefrontal slow-wave and spindle oscillations, which actively dictates the hippocampal-neocortical dialogue and information transfer. Our results suggest a model of the human sleeping brain in which rapid bidirectional interactions, triggered by the prefrontal cortex, mediate hippocampal activation to optimally time subsequent information transfer to the neocortex during NREM sleep.