The behavior of larval zebrafish reveals stressor-mediated anorexia during early vertebrate development
The behavior of larval zebrafish reveals stressor-mediated anorexia during early vertebrate development
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DOI：
10.3389/fnbeh.2014.00367
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发表时间：
2014-10-20
影响因子：
3
通讯作者：
Ryu, Soojin
中科院分区：
文献类型：
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作者：
De Marco, Rodrigo J.;Groneberg, Antonia H.;Ryu, Soojin
压力和食物消耗之间的关系在成年人中已经有了很好的记录，但在发育中的脊椎动物中却没有。在这里，我们证明遇到压力源可以抑制斑马鱼幼虫的食物消耗。此外，我们提供的证据表明，食物摄入抑制不能通过运动、氧气消耗和视觉反应的变化来解释，因为它们在暴露于强应激源后仍然不受影响。我们还表明，当皮质醇（人类和硬骨鱼的应激激素）的基础水平重新建立时，进食会再次发生。研究结果表明，压力的发生可以在脊椎动物发育的早期切断进食的动力，并为生物代谢和行为障碍的分析提供了一个新的终点，适合于高通量遗传学和非侵入性脑成像。
The relationship between stress and food consumption has been well documented in adults but less so in developing vertebrates. Here we demonstrate that an encounter with a stressor can suppress food consumption in larval zebrafish. Furthermore, we provide indication that food intake suppression cannot be accounted for by changes in locomotion, oxygen consumption and visual responses, as they remain unaffected after exposure to a potent stressor. We also show that feeding reoccurs when basal levels of cortisol (stress hormone in humans and teleosts) are re-established. The results present evidence that the onset of stress can switch off the drive for feeding very early in vertebrate development, and add a novel endpoint for analyses of metabolic and behavioral disorders in an organism suitable for high throughput genetics and non-invasive brain imaging.