Correlation between plasma and synovial fluid basic fibroblast growth factor with radiographic severity in primary knee osteoarthritis
Correlation between plasma and synovial fluid basic fibroblast growth factor with radiographic severity in primary knee osteoarthritis
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DOI：
10.1007/s00264-011-1435-z
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发表时间：
2012-05-01
影响因子：
2.7
通讯作者：
Parkpian, Vinai
中科院分区：
文献类型：
--
作者：
Honsawek, Sittisak;Yuktanandana, Pongsak;Parkpian, Vinai
为探讨原发性膝骨关节炎（OA）患者血浆和滑液中碱性成纤维细胞生长因子（bFGF）的水平及其与疾病严重程度的关系，选取35例OA患者和15例健康人作为研究对象。膝关节OA分级根据Kelling-Lawrence分级进行。采用酶联免疫吸附法测定膝关节OA患者血浆和关节液中bFGF的含量，结果表明膝关节OA患者血浆和关节液中bFGF的含量明显高于对照组（P < 0.001）。血浆和滑液bFGF浓度与放射学严重程度呈正相关（r = 0.535，P < 0.001; r = 0.570，P < 0.001）。进一步分析发现，OA患者血浆和滑液中bFGF水平呈正相关（r = 0.674，P < 0.001），OA患者血浆和滑液中bFGF水平均显著升高，且升高水平与OA的严重程度呈正相关。这些发现表明，bFGF水平可能是疾病严重程度的监测，并可能在OA退行性过程的病理生理学中发挥重要作用。
The aim of this study was to investigate plasma and synovial fluid basic fibroblast growth factor (bFGF) levels in patients with primary knee osteoarthritis (OA) and to evaluate the correlation between bFGF levels and disease severity.Thirty-five patients with knee OA and 15 healthy individuals were recruited into this study. Knee OA grading was performed according to the Kellgren-Lawrence classification. bFGF concentrations in both plasma and synovial fluid were determined using enzyme-linked immunosorbent assay.Plasma and synovial fluid bFGF levels in knee OA patients were significantly higher than in controls (P < 0.001). Moreover, plasma and synovial fluid bFGF concentrations were positively correlated with radiographic severity (r = 0.535, P < 0.001 and r = 0.570, P < 0.001, respectively). Further analysis revealed that there was a positive correlation between plasma and synovial fluid bFGF levels (r = 0.674, P < 0.001).Plasma and synovial fluid bFGF levels were significantly increased in OA patients, and these elevated levels were positively correlated with radiographic severity. These findings indicate that bFGF levels may be a monitor of disease severity and could play an essential part in the pathophysiology of degenerative process in OA.