Severe subcutaneous generalized edema in a patient with dermatomyositis.
Severe subcutaneous generalized edema in a patient with dermatomyositis.
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DOI：
10.1007/s10165-006-0560-9
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发表时间：
2007-01-01
影响因子：
2.2
通讯作者：
Mimori, Tsuneyo
中科院分区：
文献类型：
--
作者：
Ito, Yoshinaga;Kawabata, Daisuke;Mimori, Tsuneyo
与皮肌炎（DM）/多肌炎（PM）相关的皮下全身性水肿极其罕见。在此，我们报告一个严重的皮下全身水肿并发糖尿病。一位78岁的女士因四肢严重水肿在我科住院。肌酶升高、日光性皮疹、肌电图检查和肌肉活检结果证实了DM的诊断。没有其他疾病可能导致的症状表明，大量水肿与糖尿病的病理生理学相关。虽然肌病和水肿对口服泼尼松龙反应良好，但吞咽困难持续存在。结论DM/PM患者在病程中可出现皮下水肿，皮下血管病变可能参与DM/PM的发病过程。
Subcutaneous generalized edema associated with dermatomyositis (DM)/polymyositis (PM) is extremely rare. Herein we report a case of severe subcutaneous generalized edema complicating DM. A 78-year-old woman was hospitalized in our department because of massive edema in the four limbs. Elevated muscle enzymes, heliotrope rash, results of electromyography, and muscle biopsy confirmed the diagnosis of DM. The absence of other diseases that could cause the symptoms indicated that massive edema was correlated with the pathophysiology of DM. Although myopathy and edema responded well to oral prednisolone, dysphagia persisted. We conclude that subcutaneous generalized edema can occur during the course of DM/PM, and subcutaneous vasculopathy may be involved in the pathogenesis of DM/PM.