INCREASED ENDOGENOUS INTERFERON-GAMMA AND NEOPTERIN CORRELATE WITH INCREASED DEGRADATION OF TRYPTOPHAN IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION
INCREASED ENDOGENOUS INTERFERON-GAMMA AND NEOPTERIN CORRELATE WITH INCREASED DEGRADATION OF TRYPTOPHAN IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION
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DOI：
10.1016/0165-2478(91)90005-u
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发表时间：
1991-06-01
影响因子：
4.4
通讯作者：
WACHTER, H
中科院分区：
文献类型：
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作者：
FUCHS, D;MOLLER, AA;WACHTER, H
据报道，人类免疫缺陷病毒1型（HIV-1）感染患者的色氨酸浓度降低，犬尿氨酸浓度升高。从体外数据来看，活化的吲哚胺2，3-双加氧酶（IDO）参与了这种代谢变化。IDO可由干扰素-（IFN）-γ诱导。我们比较了42例HIV-1感染患者的血清IFN-γ和新蝶呤（其生物合成也可由IFN-γ诱导）与血清、色氨酸和犬尿氨酸的浓度。与HIV-1血清阴性对照组相比，IFN-γ、新蝶呤和犬尿氨酸水平显著升高，而色氨酸显著降低。色氨酸，犬尿氨酸，IFN-γ和新蝶呤浓度之间发现各种显着的相关性。新蝶呤、IFN-γ和犬尿氨酸/色氨酸商数之间的相关性最高，犬尿氨酸/色氨酸商数是IDO的产物和底物浓度之间的比率。数据表明，HIV-1血清阳性中色氨酸的减少可能是由于慢性免疫激活，并且可以被称为IDO的激活增加。
Reduced tryptophan and increased kynurenine concentrations have been reported in patients with human immunodeficiency virus type 1 (HIV-1) infection. From in vitro data it appears that activated indoleamine 2,3-dioxygenase (IDO) is involved in this metabolic change. IDO is inducible by interferon-(IFN)-gamma. We compared serum concentrations of IFN-gamma and neopterin (the biosynthesis of which is also inducible by IFN-gamma) with serum, tryptophan and kynurenine of 42 patients with HIV-1 infection.IFN-gamma, neopterin and kynurenine levels were significantly increased compared to HIV-1 seronegative controls whereas tryptophan was significantly decreased. Various significant correlations were found between tryptophan, kynurenine, IFN-gamma and neopterin concentrations. Highest degree of correlation was found between neopterin, IFN-gamma and the kynurenine per tryptophan quotient which is the ratio between the product and the substrate concentration of IDO.The data indicate that decreased tryptophan in HIV-1 seropositives may result from chronic immune activation and can be referred to increased activation of IDO.