Effects of citalopram on jaw-closing muscle activity during sleep and wakefulness in mice
Effects of citalopram on jaw-closing muscle activity during sleep and wakefulness in mice
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DOI：
10.1016/j.neures.2016.07.004
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发表时间：
2016-12-01
影响因子：
2.9
通讯作者：
Inoue, Tomio
中科院分区：
文献类型：
--
作者：
Ikawa, Yasuha;Mochizuki, Ayako;Inoue, Tomio
在这项研究中，我们研究了长期服用选择性5-羟色胺再摄取抑制剂(SSRI)西酞普兰对24小时睡眠/觉醒周期和咬肌(合下巴)肌电活动的影响。从暗到亮，觉醒次数减少，非快速眼动(NREM)和快速眼动睡眠次数增加。西酞普兰对睡眠觉醒分布的时间变化无显著影响，但可导致光周期NREM睡眠时间缩短和REM睡眠持续时间延长。此外，在任何警戒状态下，西酞普兰不改变咬肌肌电的平均活动，也不影响与暗/光周期之间的转换相关的时间变化。然而，在暗期和光期的后半段和上半段，西酞普兰分别增加了NREM睡眠中咬肌肌电激活的时间。这些结果表明，慢性西酞普兰治疗不影响睡眠觉醒分布的时间变化，但具有有限的易化影响，未能增加咬肌高水平激活的次数。(C)2016年爱思唯尔爱尔兰有限公司和日本神经科学学会。版权所有。
In this study, we investigated the effects of chronic administration of the selective serotonin reuptake inhibitor (SSRI) citalopram on sleep/wake cycles and masseter (jaw-closing) muscle electromyogram (EMG) activity over a 24-h period. From the dark to the light period, the times of wakefulness decreased, while those of non-rapid eye movement (NREM) and REM sleep increased. Citalopram did not induce major alterations in the temporal changes of sleep wake distributions, except for leading to a decrease in the time of NREM sleep during the light period and an increase in the durations of REM sleep episodes. Moreover, citalopram did not modify mean masseter EMG activity during any of the vigilance states and did not affect the temporal changes related to the shifts between dark/light periods. However, citalopram increased the time engaged in masseter EMG activation during NREM sleep in the second and the first halves of the dark and light periods, respectively. These results suggest that chronic citalopram treatment does not affect the temporal changes of sleep wake distributions, but has a limited facilitatory influence that fails to increase the number of epochs of high levels of masseter muscle activation. (C) 2016 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.