Multidimensional Mechanistic Spectrum of Long Non-coding RNAs in Heart Development and Disease.
Multidimensional Mechanistic Spectrum of Long Non-coding RNAs in Heart Development and Disease.
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DOI：
10.3389/fcvm.2021.728746
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发表时间：
2021
影响因子：
3.6
通讯作者：
Yang L
中科院分区：
文献类型：
--
作者：
Han L;Yang L
随着大规模的全基因组测序，人们发现长的非编码RNA(LncRNAs)构成了人类转录组的很大一部分。最近的研究表明，lncRNAs在心脏发育和疾病中具有多维功能。LncRNA的亚细胞定位被认为是决定其功能的关键因素。胞质中的lncRNAs主要调节mRNA的稳定性、翻译、miRNA的加工和功能，而核内的lncRNAs主要在表观遗传上调节染色质的重塑、结构和基因转录。在本文中，我们分别综述了细胞质和核lncRNAs在心脏发育和疾病中的分子机制，并着重介绍了细胞质和核lncRNAs在协调同一生物过程中的相互作用的最新进展。鉴于大多数lncRNA的进化保守性较低，对人类lncRNA的深入了解将揭示人类心脏发育和疾病潜在的新的调节机制，并有利于未来人类心脏病的临床治疗。
With the large-scale genome-wide sequencing, long non-coding RNAs (lncRNAs) have been found to compose of a large portion of the human transcriptome. Recent studies demonstrated the multidimensional functions of lncRNAs in heart development and disease. The subcellular localization of lncRNA is considered as a key factor that determines lncRNA function. Cytosolic lncRNAs mainly regulate mRNA stability, mRNA translation, miRNA processing and function, whereas nuclear lncRNAs epigenetically regulate chromatin remodeling, structure, and gene transcription. In this review, we summarize the molecular mechanisms of cytosolic and nuclear lncRNAs in heart development and disease separately, and emphasize the recent progress to dictate the crosstalk of cytosolic and nuclear lncRNAs in orchestrating the same biological process. Given the low evolutionary conservation of most lncRNAs, deeper understanding of human lncRNA will uncover a new layer of human regulatory mechanism underlying heart development and disease, and benefit the future clinical treatment for human heart disease.