Transcriptionally targeted gene therapy to detect and treat cancer.
Transcriptionally targeted gene therapy to detect and treat cancer.
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DOI：
10.1016/j.molmed.2003.08.005
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发表时间：
2003-10
影响因子：
13.6
通讯作者：
Lily Wu;Mai Johnson;Makoto Sato
中科院分区：
文献类型：
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作者：
Lily Wu;Mai Johnson;Makoto Sato
癌症治疗的最大挑战是达到最高水平的特异性和有效性。癌症基因治疗可以通过特异性设计表达治疗基因来诱导癌细胞的破坏。癌症特异性启动子是实现靶向表达的有用工具；然而，需要高水平的基因表达才能达到治疗效果。将成像报告基因与治疗基因结合在一起，可以切实证明基因表达发生在正确的位置和足够的水平。基于基因的成像可以促进癌症的检测和诊断。通过结合癌症靶向成像和治疗策略，发现隐藏的、播散的癌细胞并同时消灭它们的“组合拳”的令人兴奋的前景有可能实现。
The greatest challenge in cancer treatment is to achieve the highest levels of specificity and efficacy. Cancer gene therapy could be designed specifically to express therapeutic genes to induce cancer cell destruction. Cancer-specific promoters are useful tools to accomplish targeted expression; however, high levels of gene expression are needed to achieve therapeutic efficacy. Incorporating an imaging reporter gene in tandem with the therapeutic gene will allow tangible proof of principle that gene expression occurs at the correct location and at a sufficient level. Gene-based imaging can advance cancer detection and diagnosis. By combining the cancer-targeted imaging and therapeutic strategies, the exciting prospect of a ‘one-two punch' to find hidden, disseminated cancer cells and destroy them simultaneously can potentially be realized.