The Expression of Insulin-Like Growth Factor 2 Messenger RNA-Binding Protein 3 in Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma
The Expression of Insulin-Like Growth Factor 2 Messenger RNA-Binding Protein 3 in Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma
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DOI：
10.1620/tjem.255.27
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发表时间：
2021-09-01
影响因子：
2.2
通讯作者：
Haga, Hironori
中科院分区：
文献类型：
--
作者：
Yashige, Konomi;Kataoka, Tatsuki R.;Haga, Hironori
郎格汉斯细胞肿瘤是一种起源于树突状细胞的肿瘤，包括郎格汉斯细胞组织细胞增生症和朗格汉斯细胞肉瘤。郎格汉斯细胞肉瘤是一种高度恶性的肿瘤，具有明显的恶性细胞学特征和郎格汉斯细胞样表型，通常比郎格汉斯细胞组织细胞增生症预后更差，表型更具侵袭性。胰岛素样生长因子2信使RNA结合蛋白3(IGF2BP3或IMP3)是一种癌胎儿蛋白，表达于多种肿瘤类型，常与预后不良和侵袭性表型有关。在此，我们用免疫组织化学方法检测IGF2BP3在郎格罕斯细胞肿瘤中的表达。免疫组化法将IGF2BP3表达分为阴性(1%)或阳性(1%)。4例朗格汉斯细胞肉瘤患者(100%)和22例儿童(18岁)朗格汉斯细胞组织细胞增生症患者中6例(27.3%)IGF2BP3阳性，而22例朗格汉斯细胞组织细胞增生症患儿中16例(72.7%)和15例成人朗格汉斯细胞组织细胞增生症患者(100%)均为阴性。在朗格汉斯细胞组织细胞增生症患者中，IGF2BP3的表达与性别、部位、预后和BRAF V600E染色结果无关。综上所述，IGF2BP3的表达可能是鉴别成人朗格汉斯细胞肉瘤和朗格汉斯细胞组织细胞增生症的有用标志物。
Langerhans cell neoplasms, which include Langerhans cell histiocytosis and Langerhans cell sarcoma, are tumors that originate from dendritic cells. Langerhans cell sarcoma is defined as a high-grade neoplasm with overtly malignant cytological features and the Langerhans cell-like phenotype, and generally has a poorer prognosis and more aggressive phenotype than Langerhans cell histiocytosis. Insulin-like growth factor 2 messenger RNA-binding protein 3 (IGF2BP3 or IMP3) is an oncofetal protein that is expressed in various cancer types; its expression is often associated with a poor prognosis and aggressive phenotype. Here, we used immunohistochemistry to evaluate IGF2BP3 expression in Langerhans cell neoplasms. IGF2BP3 expression was scored as negative (< 1%) or positive (>= 1%) by immunohistochemistry. All 4 patients with Langerhans cell sarcoma (100%) and 6 of 22 pediatric (age < 18 years) patients with Langerhans cell histiocytosis (27.3%) had positive results for IGF2BP3; however, 16 of 22 pediatric patients with Langerhans cell histiocytosis (72.7%) and all 15 adult (age >= 18 years) patients with Langerhans cell histiocytosis (100%) had a negative result. Among patients with Langerhans cell histiocytosis, IGF2BP3 expression was independent of sex, location, prognosis, and BRAF V600E staining results. Taken together, these results indicate that IGF2BP3 expression may be a helpful marker for distinguishing Langerhans cell sarcoma from Langerhans cell histiocytosis in adult patients.