ACTH- and noncontingent footshock-induced recovery of an extinguished passive avoidance response.
ACTH- and noncontingent footshock-induced recovery of an extinguished passive avoidance response.
复制标题
ACTH 和非偶然足部电击引起的被动回避反应消失的恢复。
DOI：
10.1016/0031-9384(87)90117-x
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发表时间：
1987
影响因子：
2.9
通讯作者：
Riccio,DC
中科院分区：
文献类型：
--
作者：
Lashley,RL;Richardson,R;Riccio,DC
评估了外源性促肾上腺皮质激素和非偶然足震作为恢复已消失的被动回避反应的药物的有效性。6组雄性Holtzman大鼠分别在保留测试前15分钟、24小时或7天给予促肾上腺皮质激素（4IU）或单次非偶然足震。两个对照组在试验前15分钟或7天注射无活性凝胶载体。在试验前15分钟或24小时给予促肾上腺皮质激素，以及在试验前24小时（但不是15分钟）给予非偶然足震，作为有效的恢复剂。实质性的“自发恢复”排除了在7天的保留间隔内评估恢复效果。这种持续至少24小时的恢复与促肾上腺皮质激素和非偶发足震不仅增强了原始恐惧条件反射的记忆检索，而且使训练记忆进一步加工的观点是一致的。
The effectiveness of both exogenous adrenocorticotropic hormone and noncontingent footshock as agents for the recovery of an extinguished passive avoidance response was assessed. Six groups of male Holtzman rats were administered either adrenocorticotropic hormone (4IU), or a single noncontingent footshock, either 15 minutes, 24 hours, or 7 days prior to retention testing. Two control groups received an injection of the inactive gel vehicle either 15 minutes or 7 days prior to test. Adrenocorticotropic hormone administered either 15 minutes or 24 hours prior to test, as well as noncontingent footshock delivered 24 hours (but not 15 minutes) prior to test, served as effective reinstatement agents. Substantial “spontaneous recovery” of responding precluded evaluation of reinstatement effects at the 7 day retention interval. The persistence of the recovery for at least 24 hours is consistent with the notion that both adrenocorticotropic hormone and noncontingent footshock not only enhance memory retrieval of the original fear conditioning, but also cause the training memory to be further processed.