Genetic variation in Chlamydia trachomatis and their hosts: impact on disease severity and tissue tropism.
Genetic variation in Chlamydia trachomatis and their hosts: impact on disease severity and tissue tropism.
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DOI：
10.2217/fmb.13.80
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发表时间：
2013-09
影响因子：
3.1
通讯作者：
Byrne GI
中科院分区：
文献类型：
--
作者：
Abdelsamed H;Peters J;Byrne GI
沙眼衣原体感染是一个全球性的健康问题。这种专性细胞内细菌病原体包括淋巴肉芽肿(L1-L3)、眼部(A-C)和生殖器(D-K)血清型。虽然遗传上相似，但每个血清型组在疾病严重程度和组织趋向性方面都不同，其机制尚不清楚。很明显，宿主遗传差异也在衣原体疾病的结果中发挥作用，关键的宿主多态开始出现在人类和实验动物的研究中。在这篇综述中，我们将重点介绍与遗传多样性、疾病严重性和组织嗜性相关的病原体和宿主基因。我们还将利用这些信息提供新的见解，这些见解可能有助于制定针对这些重要病原体的改进管理策略。
Chlamydia trachomatis infections are a global health problem. This obligate intracellular bacterial pathogen comprises lymphogranuloma venereum (L1–L3), ocular (A–C) and genital (D–K) serovars. Although genetically similar, each serovar group differs in disease severity and tissue tropism through mechanisms that are not well understood. It is clear that host genetic differences also play a role in chlamydial disease outcome and key host polymorphisms are beginning to emerge from both human and experimental animal studies. In this review, we will highlight pathogen and host genes that link genetic diversity, disease severity and tissue tropism. We will also use this information to provide new insights that may be helpful in developing improved management strategies for these important pathogens.