Purpura fulminans in severe congenital protein C deficiency: Monitoring of treatment with protein C concentrate
Purpura fulminans in severe congenital protein C deficiency: Monitoring of treatment with protein C concentrate
复制标题
严重先天性蛋白 C 缺乏症中的暴发性紫癜：浓缩蛋白 C 治疗的监测
DOI：
10.1007/bf02115621
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发表时间：
2005
影响因子：
3.6
通讯作者：
D. Schranz
中科院分区：
文献类型：
--
作者：
F. Müller;W. Ehrenthal;G. Hafner;D. Schranz
This report describes the successful use of protein C concentrate to treat severe purpura fulminans in a homozygous protein C-deficient infant for 8 months until oral anticoagulation was initiated. While fresh frozen plasma was previously used in such cases to replace protein C in the acute phase, the availability of a monoclonal antibody purified protein C concentrate now allows specific replacement of protein C, avoiding problems of fluid overload. An occlusive-hydrocolloid bandage proved to be effective in local treatment of skin lesions. D-dimer, fibrin monomer, thrombin-antithrombin complex and prothrombin fragment 1+2 were useful markers in monitoring and optimizing protein C replacement therapy.
使用单克隆抗体纯化蛋白 C 浓缩物治疗香豆素诱导的皮肤坏死。
影响因子：
--
作者：
Schramm,W;Spannagl,M;Bauer,KA;Rosenberg,RD;Birkner,B;Linnau,Y;Schwarz,HP
通讯作者：
Schwarz,HP