Differences in somatic perception in female patients with irritable bowel syndrome with and without fibromyalgia
Differences in somatic perception in female patients with irritable bowel syndrome with and without fibromyalgia
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DOI：
10.1016/s0304-3959(99)00215-8
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发表时间：
2000-02-01
期刊：
影响因子：
7.4
通讯作者：
Naliboff, B
中科院分区：
文献类型：
--
作者：
Chang, L;Mayer, EA;Naliboff, B
背景：肠易激综合征（IBS）和纤维肌痛（FM）分别被认为是内脏和躯体知觉改变的慢性综合征。由于 IBS 和 FM 存在显着重叠，因此有人提出了共同的病理生理机制。尽管肠易激综合征的内脏知觉已得到充分研究，但躯体知觉尚无定论。目的：比较 IBS、IBS + FM 和健康对照患者对躯体刺激的过度警觉和感觉知觉改变。方法：11 名 IBS 女性（平均年龄 40 岁）、11 名 IBS + FM 女性（平均年龄 46 岁）和 10 名健康女性对照（平均年龄 39 岁）评估对主动躯体压痛点、非渲染控制点和 T-12 皮节施加的压力刺激的疼痛感知，这些刺激以可预测的上升序列传递，并以不可预测的随机方式（固定刺激）传递。结果。尽管与对照组相比，IBS患者在上升系列中具有相似的疼痛阈值，但与IBS + FM患者和对照组相比，在固定刺激系列中，IBS患者出现躯体痛觉减退，疼痛阈值较高，疼痛频率和严重程度较低（P < 0.05）。IBS + FM患者更受躯体刺激困扰，出现躯体痛觉过敏，疼痛阈值较低，疼痛频率和严重程度较高。结论：过度警觉和躯体痛觉减退都会导致 IBS 患者躯体知觉的改变。 FM 的共病导致 IBS 患者出现躯体痛觉过敏。 (C) 2000 年国际疼痛研究协会。由 Elsevier Science B.V. 出版
Background: Irritable bowel syndrome (IBS) and fibromyalgia (FM) an considered chronic syndromes of altered visceral and somatic perception, respectively. Because there is a significant overlap of IBS and FM, shared pathophysiological mechanisms have been suggested. Although visceral perception has been well studied in IBS, somatic perception has npt. Aims: To compare hypervigilance and altered sensory perception in response to somatic stimuli in patients with IBS, IBS + FM, and healthy controls. Methods: Eleven IBS females (mean age 40), 11 IBS + FM females (mean age 46), and ten healthy female controls (mean age 39) rated pain perception in response to pressure stimuli administered to active somatic tender points, non-render control points and the T-12 dermatome, delivered in a predictable ascending series, and delivered in an unpredictable randomized fashion (fixed stimulus). Results. Although IBS patients had similar pain thresholds during the ascending series compared with controls, they were found to have somatic hypoalgesia with higher pain thresholds and lower pain frequency and severity during fixed stimulus series compared with IBS + FM patients and controls (P < 0.05), Patients with IBS + FM were more bothered by the somatic stimuli and had somatic hyperalgesia with lower pain thresholds and higher pain frequency and severity. Conclusions: Both hypervigilance and somatic hypoalgesia contribute to the altered somatic perception in IBS patients. Co-morbidity with FM results in somatic hyperalgesia in IBS patients. (C) 2000 International Association for the Study of Pain. Published by Elsevier Science B.V.