In vitro degradation of polymeric networks of poly(propylene fumarate) and the crosslinking macromer poly(propylene fumarate)-diacrylate
In vitro degradation of polymeric networks of poly(propylene fumarate) and the crosslinking macromer poly(propylene fumarate)-diacrylate
复制标题
DOI：
10.1016/s0142-9612(02)00368-x
复制
发表时间：
2003-02-01
期刊：
影响因子：
14
通讯作者：
Mikos, AG
中科院分区：
文献类型：
--
作者：
Timmer, MD;Ambrose, CG;Mikos, AG
目前正在研究聚富马酸丙二醇酯（PPF）与聚富马酸丙二醇酯-二丙烯酸酯（PPF-DA）交联的聚合物网络作为可注射的可生物降解骨水泥。本研究考察了交联密度、介质pH值和β-磷酸三钙（β-TCP）填料对PPF/PPF-DA体外降解的影响。将圆柱形试样浸没在37 ℃的缓冲盐水中，在52周的时间内监测重量、几何形状和压缩力学性能的变化。所有制剂在前12周内显示出模量和屈服强度的初始增加，对于β-TCP复合材料分别达到1307 +/- 101和51 +/- 3 MPa的最大值。具有较低交联密度的PPF/PPF-DA网络表现出最大的降解，质量损失为17%。与生理pH 7.4相比，在较低的缓冲液pH 5.0中的样品没有显示出质量损失的任何差异，但随着时间的推移，抗压强度降低得更快。β-TCP复合材料的力学性能保持在其初始增加后的水平。这些结果表明，PPF/PPF-DA网络的降解可以通过交联密度来控制，在较低的pH下加速，并且随着β-TCP填料的掺入而延长。(C)2002爱思唯尔科技有限公司版权所有。
Polymeric networks of poly(propylene fumarate) (PPF) crosslinked with poly(propylene fumarate)-diacrylate (PPF-DA) are currently being investigated as an injectable, biodegradable bone cement. This study examined the effect of crosslinking density, medium pH, and the incorporation of a beta-tricalcium phosphate (beta-TCP) filler on the in vitro degradation of PPF/PPF-DA. Cylindrical specimens were submerged in buffered saline at 37degreesC and the change in weight, geometry, and compressive mechanical properties were monitored over a 52-week period. All formulations showed an initial increase in modulus and yield strength over the first 12 weeks, achieving maxima of 1307 +/- 101 and 51 +/- 3 MPa, respectively, for the beta-TCP composite. PPF/PPF-DA networks with the lower crossfinking density demonstrated the greatest degradation with a 17% mass loss. Samples in the lower buffer pH 5.0 compared to physiological pH 7.4 did not show any differences in mass loss, but exhibited a faster decrease in the compressive strength over time. The beta-TCP composites maintained their mechanical properties at the level following their initial increase. These results show that the degradation of PPF/PPF-DA networks can be controlled by the crosslinking density, accelerated at a lower pH, and prolonged with the incorporation of the beta-TCP filler. (C) 2002 Elsevier Science Ltd. All rights reserved.