Towards an integrative genomics of lung function.

Towards an integrative genomics of lung function.
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走向肺功能的综合基因组学。

DOI:
10.1016/s2213-2600(15)00362-8
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发表时间:
2015
期刊:
The Lancet. Respiratory medicine
影响因子:
--
通讯作者:
Cho,MichaelH
Cho,MichaelH
中科院分区:
--
文献类型:
--
作者:
Cho,MichaelH

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Genetic variation is an important determinant of lung function and risk of chronic obstructive pulmonary disease (COPD). Genome-wide association studies (GWAS), first described a decade ago, have become the standard method to study genetic factors influencing these and other complex (non-mendelian) traits and diseases. GWAS can be used to identify novel biological pathways for human disease and ultimately inform diagnostics and therapeutics. 1 However, they have several limitations. One is a lack of power. Although GWAS in most diseases have identified at least a few genetic loci, important insights can only be gained when patterns among many loci are recognised. 2 To detect such patterns, however, large sample sizes are needed, and these can be difficult to achieve. Another major limitation is that GWAS generally implicate regions of the genome rather than specific genes or pathophysiological mechanisms.
DOI: 10.1038/nature12531
发表时间: 2013-09-26
期刊: Nature
影响因子: 64.8
作者:
通讯作者: --
DOI: 10.1038/nature13595
发表时间: 2014-07-24
期刊: NATURE
影响因子: 64.8
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