Associative pairing of tactile stimulation induces somatosensory cortical reorganization in rats and humans
Associative pairing of tactile stimulation induces somatosensory cortical reorganization in rats and humans
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DOI：
10.1097/00001756-199612200-00056
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发表时间：
1996-12-20
期刊：
影响因子：
1.7
通讯作者：
Dinse, HR
中科院分区：
文献类型：
--
作者：
Godde, B;Spengler, F;Dinse, HR
我们使用触觉刺激联想（赫布）配对（APTS）协议来引起皮质可塑性变化。 Reversible reorganization of the adult rat paw representations in somatosensory cortex (SI) induced by a few hours of APTS included selective enlargement of the areas of cortical neurones representing the stimulated skin fields and of the corresponding receptive fields (RFs).后期，可能是 NMDA 受体介导的反应成分增强，表明谷氨酸能突触的参与。 A control protocol of identical stimulus pattern applied to only a single skin site revealed no changes of RFs, indicating that co-activation is crucial for induction. Using an analogous APTS protocol in humans revealed an increase of spatial discrimination performance indicating that fast plastic processes based on co-activation patterns act on a cortical and perceptual level.
WE used a protocol of associative (Hebbian) pairing of tactile stimulation (APTS) to evoke cortical plastic changes. Reversible reorganization of the adult rat paw representations in somatosensory cortex (SI) induced by a few hours of APTS included selective enlargement of the areas of cortical neurones representing the stimulated skin fields and of the corresponding receptive fields (RFs). Late, presumably NMDA receptor-mediated response components were enhanced, indicating an involvement of glutamatergic synapses. A control protocol of identical stimulus pattern applied to only a single skin site revealed no changes of RFs, indicating that co-activation is crucial for induction. Using an analogous APTS protocol in humans revealed an increase of spatial discrimination performance indicating that fast plastic processes based on co-activation patterns act on a cortical and perceptual level.