Are innate immune signaling pathways in plants and animals conserved?
Are innate immune signaling pathways in plants and animals conserved?
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DOI：
10.1038/ni1253
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发表时间：
2005-10-01
影响因子：
30.5
通讯作者：
Ausubel, FM
中科院分区：
文献类型：
--
作者：
Ausubel, FM
虽然适应性免疫是脊椎动物所特有的，但先天免疫反应似乎有着古老的起源。脊椎动物、无脊椎动物和植物先天免疫的共同特征包括明确的微生物相关分子受体、保守的丝裂原相关蛋白激酶信号级联以及抗菌肽的产生。据普遍报道，先天免疫的这些相似性代表了一种古老的单细胞真核生物的不同进化过程，这种生物早于植物和动物王国的分化。然而，目前的数据表明，植物和动物先天免疫中使用的看似相似的调节模块是趋同进化的结果，反映了先天免疫系统如何构建的内在限制。
Although adaptive immunity is unique to vertebrates, the innate immune response seems to have ancient origins. Common features of innate immunity in vertebrates, invertebrate animals and plants include defined receptors for microbe-associated molecules, conserved mitogen-associated protein kinase signaling cascades and the production of antimicrobial peptides. It is commonly reported that these similarities in innate immunity represent a process of divergent evolution from an ancient unicellular eukaryote that pre-dated the divergence of the plant and animal kingdoms. However, at present, data suggest that the seemingly analogous regulatory modules used in plant and animal innate immunity are a consequence of convergent evolution and reflect inherent constraints on how an innate immune system can be constructed.