COMPARISON OF THE EFFECTS OF FLAVONE ACETIC-ACID, FOSTRIECIN, HOMOHARRINGTONINE AND TUMOR NECROSIS FACTOR-ALPHA ON COLON-38 TUMORS IN MICE
COMPARISON OF THE EFFECTS OF FLAVONE ACETIC-ACID, FOSTRIECIN, HOMOHARRINGTONINE AND TUMOR NECROSIS FACTOR-ALPHA ON COLON-38 TUMORS IN MICE
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DOI：
10.1016/0277-5379(89)90018-7
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发表时间：
1989-02-01
期刊：
影响因子：
--
通讯作者：
SMITH, GP
中科院分区：
文献类型：
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作者：
BAGULEY, BC;CALVELEY, SB;SMITH, GP
使用小鼠中的晚期皮下Colon 38肿瘤评估多种抗癌药物的活性。活性通过单次给药后24小时的肿瘤组织学检查来测量，在某些情况下通过肿瘤生长延迟来测量。被认为通过损伤DNA发挥其细胞毒性作用的药物，包括阿霉素、安吖啶及其类似物CI-921、环磷酰胺、5-氟尿嘧啶和甲氨蝶呤，在24小时后没有产生大体组织学变化，尽管有些药物延迟了皮下肿瘤的生长。相比之下，黄酮乙酸，fostriecin和homoharringtonine引起广泛的肿瘤坏死后24小时，和每个延迟晚期皮下肿瘤的生长至少10天，当作为一个单一的剂量给药。黄酮乙酸和fostriecin的组织学作用与重组人肿瘤坏死因子α的组织学作用没有区别。有人建议，晚期肿瘤的组织学检测可能提供一个有用的辅助现有的方法在筛选抗肿瘤药物与新的作用机制。
Advanced subcutaneous Colon 38 tumours in mice were used for the assessment of activity of a number of anticancer drugs. Activity was measured by histological examination of tumours 24 h after a single dose of the drug and in some cases by tumour growth delay. Agents thought to exert their cytotoxic effect by damaging DNA, including Adriamycin, amsacrine and its analogue CI-921, cyclophosphamide, 5-fluorouracil and methotrexate produced no gross histological changes after 24 h, even though some delayed the growth of subcutaneous tumours. In contrast, flavone acetic acid, fostriecin and homoharringtonine caused extensive necrosis of tumours after 24 h, and each delayed the growth of advanced subcutaneous tumours by at least 10 days when administered as a single dose. The histological effects of flavone acetic acid and fostriecin were indistinguishable from those of recombinant human tumor necrosis factor .alpha.. It is proposed that histological assay of advanced tumours may provide a useful adjunct to existing methods in screening for antitumor agents with novel mechansims of action.