STRUCTURES OF BENZO(A)PYRENE NUCLEIC ACID ADDUCTS FORMED IN HUMAN AND BOVINE BRONCHIAL EXPLANTS
STRUCTURES OF BENZO(A)PYRENE NUCLEIC ACID ADDUCTS FORMED IN HUMAN AND BOVINE BRONCHIAL EXPLANTS
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DOI：
10.1038/269348a0
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发表时间：
1977-01-01
期刊：
影响因子：
64.8
通讯作者：
HARRIS, C
中科院分区：
文献类型：
--
作者：
JEFFREY, AM;WEINSTEIN, IB;HARRIS, C
Simset等人发表的文献证明，苯并（a）芘（BP）的7，8-二氢二醇-9，10-氧化物是仓鼠胚胎细胞中这种普遍存在的多环芳烃与DNA共价结合的代谢中间体1，随后发表了许多相关文献2。Groveret等人3也获得了证据，证明BP与人支气管外植体DNA的结合也涉及相同的衍生物，尽管没有报道所涉及的具体异构体和加合物结构的细节。我们在这里描述的RNA和DNA加合物形成的人支气管外植体的研究，并提供证据表明，主要的加合物的结构是类似的，在类似的牛系统中形成的。
PUBLICATION by Simset al.of evidence that the 7,8-dihydrodiol-9,10-oxide of benzo(a)pyrene (BP) is a metabolic intermediate in the covalent binding of this ubiquitous polycyclic aromatic hydrocarbon to DNA in hamster embryo cells1was followed by many related publications2. Groveret al.3also obtained evidence that the same derivative is involved in the binding of BP to the DNA of human bronchial explants, although details of the specific isomer involved and of the structure of the adduct were not reported. We describe here studies on RNA and DNA adducts formed by human bronchial explants and provide evidence that the structures of the major adducts are similar to those formed in the analogous bovine system.