Very high-resolution three-dimensional functional MRI of the human visual cortex with elimination of large venous vessels
Very high-resolution three-dimensional functional MRI of the human visual cortex with elimination of large venous vessels
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DOI：
10.1002/nbm.1158
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发表时间：
2007-08-01
影响因子：
2.9
通讯作者：
Norris, D. G.
中科院分区：
文献类型：
--
作者：
Barth, M.;Norris, D. G.
我们提出了一个非常高的分辨率，三维（3D）梯度回波技术与双重并行成像加速使用专门的枕部接收线圈在3 T进行功能性磁共振成像（fMRI）的视觉皮层。这种配置使得可以在与块设计兼容的时间尺度内获取3D fMRI数据。在没有进一步处理的情况下，在0.42 μ L（0.75 mm体素尺寸）的各向同性3D分辨率和1.2 μ L（1mm体素尺寸）的近各向同性分辨率下的功能图在视觉区域中显示出非常稳健的激活，但是具有来自较大静脉的明显污染。由于该技术允许在功能扫描中直接识别静脉，因此允许从激活图中去除其影响。在我们的研究中，消除静脉定性地提高了激活图的空间特异性，同时减少了约25%的激活体积。所提出的技术提供了解剖扫描的分辨率的功能信息，被定位到灰质，并有利于功能解剖配准，因为最小的失真。版权所有（C）2007约翰威利父子有限公司
We propose a very high-resolution, three-dimensional (3D) gradient-echo technique with a twofold parallel imaging acceleration using a specialized occipital receiver coil at 3 T to perform functional MRI (fMRI) of the visual cortex. This configuration makes it possible to acquire 3D fMRI data within a timescale compatible with a block design. Without further processing, the functional maps at an isotropic 3D resolution of 0.42 mu L (0.75 mm voxel size) and near-isotropic resolution of 1.2 mu L (I ram voxel size) show very robust activation in visual areas, but with clear contamination from larger veins. As this technique allows direct identification of veins in the functional scan, it permits removal of their effect from the activation maps. In our study, elimination of veins qualitatively improves the spatial specificity of activation maps, while reducing the activated volume by about 25%. The proposed technique provides functional information at the resolution of anatomical scans, is localized to gray matter, and facilitates functional to anatomical co-registration because of minimal distortions. Copyright (C) 2007 John Wiley & Sons, Ltd.