Histological studies of bone from normocalcemic post-menopausal osteoporotic patients with increased circulating parathyroid hormone.
Histological studies of bone from normocalcemic post-menopausal osteoporotic patients with increased circulating parathyroid hormone.
复制标题
对血钙正常、循环甲状旁腺激素增加的绝经后骨质疏松症患者骨的组织学研究。
DOI：
10.1210/jcem-42-3-537
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
L. Avioli
中科院分区：
文献类型：
--
作者：
S. Teitelbaum;E. Rosenberg;C. Richardson;L. Avioli
Quantitative histological evaluations were made of nondecalcified iliac crest needle biopsies were obtained from 16 untreated, normocalcemic, normophosphatemic postmenopausal osteopenic females. Six of the patients had elevated circulating immunoreactive parathyroid hormone. Morphometric parameters, which were significantly increased in the hyperparathyroid group compared with the euparathyroid patients were the cortical osteoclast count and the percentage of trabecular surface covered by active or inactive osteoid. In addition, in all patients, the cortical osteoclast count, and the per cent of trabecular surface covered by osteoid and inactive osteoid were directly related to levels of immunoreactive parathyroid hormone. These data suggest that progressive osteopenia in some patients with crush fracture, or postmenopausal or senile osteoporosis, may be conditioned by an osteoclastosis, elevations in circulating parathyroid hormone, and a relative increase in poorly mineralized osteoid tissue. As such they emphasize the heterogeneity of a so-called "osteoporotic population" and stress the need for specific histological morphometric evaluation of bone before initiating long-term therapeutic modalities.
