Relative survival rates and patterns of diagnosis analyzed by time period for individuals with primary malignant brain tumor, 1973-1997
Relative survival rates and patterns of diagnosis analyzed by time period for individuals with primary malignant brain tumor, 1973-1997
复制标题
DOI：
10.3171/jns.2003.99.3.0458
复制
发表时间：
2003-09-01
影响因子：
4.1
通讯作者：
Schwartz, AG
中科院分区：
文献类型：
--
作者：
Barnholtz-Sloan, JS;Sloan, AE;Schwartz, AG
Object.本研究的目的是检查1973年至1997年间诊断为原发性恶性脑肿瘤的患者的诊断模式和相对生存率;对这些患者的随访审查持续到1999年底。研究人群由1973年至1997年诊断的21，493例原发性恶性脑肿瘤患者组成。这些患者的数据来自基于人群的监测、流行病学和最终结果项目。研究人群根据诊断年份分为三个队列，通过卡方检验和相对生存分析，使用寿命表方法对这些组进行相关变量的比较。随着时间的推移，男性、白人、接受手术的患者以及70岁及以上的患者中，接受原发性恶性脑肿瘤诊断的患者始终较多。星形细胞瘤（其他）、少突胶质细胞瘤（其他）和少突胶质细胞瘤患者比例的检查。III级表现出显着的颞叶变化与额叶和颞叶肿瘤发生的最常见的。非裔美国人的诊断年龄早于白人患者。高加索人多形性胶质母细胞瘤（GBM）和少突胶质细胞瘤（其他）的比例较高，这与生存时间缩短相关，而非裔美国人星形细胞瘤（其他）、11级或III级室管膜瘤和髓母细胞瘤的比例较高，所有这些都与生存时间延长相关。相对生存率病例显示随着时间的推移持续改善，尽管老年患者、仅接受活检的患者和GBM患者的生存时间仍然最短。当按预后因素分层时，非裔美国人的相对生存率始终与白人相似或更差。随着时间的推移，患有原发性恶性脑肿瘤的个体的相对存活率有所提高，并且通过检查患者的种族可以看到存活率的差异。
Object. The purpose of this study was to examine patterns of diagnosis and relative survival rates in individuals in whom a primary malignant brain tumor was diagnosed between 1973 and 1997; follow-up review of these patients continued through the end of 1999.Methods. The study population was composed of 21,493 patients with primary malignant brain tumors that were diagnosed between 1973 and 1997. Data on these patients were obtained from the population-based Surveillance, Epidemiology, and End Results Program. The study population was divided into three cohorts based on the year of diagnosis, and these groups were compared with respect to variables of interest by performing chi-square tests and relative survival analysis with the life table method.Over time, there were consistently more men, more Caucasians, more patients undergoing surgery, and more individuals 70 years and older who received the diagnosis of primary malignant brain tumor. An examination of proportions of individuals with astrocytoma, other; oligodendroglioma, other; and oligodendroglioma. Grade III showed significant temporal changes with frontal and temporal lobe tumors occurring most often. The diagnosis was obtained at an earlier age in African-American than in Caucasian patients. Caucasians had higher proportions of glioblastoma multiforme (GBM), which was associated with decreased survival times, and of oligodendroglioma, other, whereas African Americans had higher proportions of astrocytoma, other; ependymoma Grade 11 or III; and medulloblastoma, all of which were associated with increased survival times. The relative survival case demonstrated a continuous improvement over time, although older patients, those who underwent biopsy only, and those with GBMs continue to have the poorest survival times. The relative survival rates of African Americans consistently were similar or worse than those of Caucasians when the groups were stratified by prognostic factors.Conclusions. Over time, the relative survival rate of individuals with primary malignant brain tumor has improved and differences in survival are seen by examining the race of the patients.