The herpes simplex virus type 1 reactivation function lies outside the latency-associated transcript open reading frame ORF-2.
The herpes simplex virus type 1 reactivation function lies outside the latency-associated transcript open reading frame ORF-2.
复制标题
1 型单纯疱疹病毒再激活功能位于潜伏期相关转录本开放阅读框 ORF-2 之外。
DOI：
10.1128/jvi.67.6.3653-3655.1993
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发表时间：
1993
影响因子：
5.4
通讯作者：
Feldman,LT
中科院分区：
文献类型：
--
作者：
Farrell,MJ;Hill,JM;Margolis,TP;Stevens,JG;Wagner,EK;Feldman,LT
潜伏相关的转录单位已被证明对单纯疱疹病毒从潜伏状态的体内再激活是重要的。构建了一种重组病毒来改变该区域最大的开放阅读框。该病毒具有野生型再激活表型，这表明单纯疱疹病毒不需要该阅读框中的蛋白质功能来有效地从潜伏中再激活。
The latency-associated transcription unit has been shown to be important for in vivo reactivation of herpes simplex virus from the latent state. A recombinant virus was constructed to alter the largest open reading frame in this region. This virus had a wild-type reactivation phenotype, suggesting that herpes simplex virus does not require a protein function from this reading frame for efficient reactivation from latency.