Clinical characteristics of rehospitalized patients with COVID-19 in China
Clinical characteristics of rehospitalized patients with COVID-19 in China
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DOI：
10.1002/jmv.26002
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发表时间：
2020-06-09
影响因子：
12.7
通讯作者：
Zhang, Mingwei
中科院分区：
文献类型：
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作者：
Chen, Min;An, Wei;Zhang, Mingwei
本研究旨在观察逆转录聚合酶链反应（RT-PCR）或血清抗体阳性的2019冠状病毒病（COVID-19）康复患者的临床特征。提取了 11 名出院后经 RT-PCR 或血清抗体检测为 COVID-19 阳性并于 2020 年 3 月入住江汉大学湖北省第三人民医院进行第二次治疗的患者的概况、临床症状、实验室结果和放射学评估。首次出院与第二次入院之间的平均间隔时间为 16.00 +/- 7.14 天，范围为 6 至 27 天。第二次住院时，1例患者RT-PCR和血清抗体免疫球蛋白M（IgM）-免疫球蛋白G（IgG）阳性，5例患者IgM和IgG均阳性，但RT-PCR阴性。 3 名患者 RT-PCR 和 IgG 均呈阳性，但 IgM 呈阴性。第二次住院时主要症状为咳嗽（54.55%）、发热（27.27%）、乏力（27.27%）。与第一次住院相比，第二次住院时胃肠道症状显着减轻（5 vs 0，P = .035），白细胞计数（P = .036）和淋巴细胞计数（P = .002）水平升高，C反应蛋白和血清淀粉样蛋白A显着降低（P < .05）。此外，六名患者的胸部计算机断层扫描（CT）显示急性渗出性病变有显着改善。出院患者的 RT-PCR 分析或血清 IgM-IgG 可能会出现阳性结果，即使临床症状较轻，但其实验室结果和胸部 CT 图像并不能表明这些患者的病情持续发展。
This study aims to observe the clinical characteristics of recovered patients from Coronavirus Disease 2019 (COVID-19) with positive in reverse transcription-polymerase chain reaction (RT-PCR) or serum antibody. The profile, clinical symptoms, laboratory outcomes, and radiologic assessments were extracted on 11 patients, who tested positive for COVID-19 with RT-PCR or serum antibody after discharged and was admitted to Hubei No. 3 People's Hospital of Jianghan University for a second treatment in March 2020. The average interval time between the first discharge and the second admission measured 16.00 +/- 7.14 days, ranging from 6 to 27 days. In the second hospitalization, one patient was positive for RT-PCR and serum antibody immunoglobulin M (IgM)-immunoglobulin G (IgG), five patients were positive for both IgM and IgG but negative for RT-PCR. Three patients were positive for both RT-PCR and IgG but negative for IgM. The main symptoms were cough (54.55%), fever (27.27%), and feeble (27.27%) in the second hospitalization. Compared with the first hospitalization, there were significant decreases in gastrointestinal symptoms (5 vs 0, P = .035), elevated levels of both white blood cell count (P = .036) and lymphocyte count (P = .002), remarkedly decreases in C-reactive protein and serum amyloid A (P < .05) in the second hospitalization. Additionally, six patients' chest computed tomography (CT) exhibited notable improvements in acute exudative lesions. There could be positive results for RT-PCR analysis or serum IgM-IgG in discharged patients, even with mild clinical symptoms, however, their laboratory outcomes and chest CT images would not indicate the on-going development in those patients.