Magnetic handling of droplet in micro chemical analysis system utilizing surface tension and wettability
Magnetic handling of droplet in micro chemical analysis system utilizing surface tension and wettability
复制标题
利用表面张力和润湿性对微化学分析系统中的液滴进行磁性处理
DOI：
10.1109/mems.2004.1290596
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
K. Sato
中科院分区：
文献类型：
--
作者：
M. Shikida;K. Inouchi;H. Honda;K. Sato
我们提出了一种用于微化学分析系统的液滴处理机制。通过使用不同液体的润湿性和表面张力，我们实现了可靠的磁性液滴处理，而样品珠不会粘附在玻璃表面。我们还开发了一种包含珠子的液滴的分离和融合机制，并证实我们的设备可以通过结合所提出的分离和融合单元来有效地冷凝和冲洗珠子。含有珠子的分离液滴的体积为30 nl，并且我们能够通过使用新鲜液滴的融合来新鲜漂洗液滴1600次，从而在一系列分离和融合操作中漂洗珠子。该系统的主要优点是不需要泵、阀门和过滤器等机械设备来处理溶液。
We propose a droplet handling mechanism for micro-chemical analysis systems. We enabled reliable magnetic droplet handling without sample beads sticking to the glass surface by using different liquids' wettability and surface tension. We also developed a separation- and fusion-mechanism of droplets containing beads, and confirmed that our device can effectively condense and rinse the beads by combining the proposed separation and fusion units. The volume of separated droplets containing beads was 30 nl, and we were able to rinse the beads in a series of separation and fusion operations by freshly rinsing droplets 1600 times using the fusion of fresh droplet. The primary advantage of the system is that it doesn't need mechanical devices such as a pump, a valve, and a filter, for handling the solution.