Inactivation of the lateral septum blocks fox odor-induced fear behavior
Inactivation of the lateral septum blocks fox odor-induced fear behavior
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DOI：
10.1097/wnr.0b013e3282fb78d9
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发表时间：
2008-04-16
期刊：
影响因子：
1.7
通讯作者：
Fendt, Markus
中科院分区：
文献类型：
--
作者：
Endres, Thomas;Fendt, Markus
许多损伤研究表明，外侧隔在先天性恐惧的调制中起着重要作用。此外，增加c-fos表达的外侧隔后，暴露于自然捕食者气味和2，3，5，-三甲基-3-噻唑啉（TMT），狐狸气味的一个组成部分。本研究从行为学的角度探讨外侧隔是否在TMT引起的恐惧中起作用。通过局部蝇蕈醇注射暂时灭活侧隔明显阻断了TMT诱导的恐惧行为，但在受控条件下对行为没有影响。这表明，侧隔是重要的处理TMT引起的恐惧，并建议侧隔也参与了自然捕食气味引起的恐惧行为。
A number of lesion studies have shown that the lateral septum plays an important role in the modulation of innate fear. Furthermore, an increased c-fos expression in the lateral septum was demonstrated after exposure to natural predator odors and 2,3,5,-trimethyl-3-thiazoline (TMT), a component of fox odor. This study investigates, on a behavioral level, whether the lateral septum plays a role in TMT-induced fear. Temporary inactivation of the lateral septum by local muscimol injections clearly blocked TMT-induced fear behavior but had no effect on behavior in a controlled condition. This indicates that the lateral septum is important for the processing of TMT-induced fear and suggests that the lateral septum is also involved in fear behavior induced by natural predator odors.