Left hemisphere contribution to motor programming of aphasic speech: A reaction time experiment in aphasic patients
Left hemisphere contribution to motor programming of aphasic speech: A reaction time experiment in aphasic patients
复制标题
左半球对失语症言语运动编程的贡献：失语症患者的反应时间实验
DOI：
10.1016/0028-3932(88)90108-x
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发表时间：
1988
期刊：
影响因子：
2.6
通讯作者：
A. Basso
中科院分区：
文献类型：
--
作者：
G. Vallar;R. Sterzi;A. Basso
在10名流利和10名不流利的右利手慢性失语症患者中研究了对偏侧视觉点刺激的简单反应时。除了标准的简单反应时间条件外，患者还接受了一项伴随的口头任务，要求在对视觉刺激做出反应时进行明显的发音。与控制条件相比，在这两个失语症组的言语任务产生了一个整体laveling延长，与一个显着放缓的反应，位于右视觉半场的刺激。根据这些结果，言语并发活动似乎涉及正常受试者的左半球，这表明左半球未受损的区域在失语症言语的运动编程中发挥作用。作为一个附带的发现，在运动障碍的患者中，同侧和对侧对刺激的潜伏期的差异（一种测量大脑半球间传输时间的方法）大大增加。这与在简单的视觉运动反应时间中，大脑半球间的转移发生在大脑前部区域之间的观点一致。
Simple reaction time to lateralized visual dot stimuli was studied in 10 fluent and 10 non-fluent right-handed chronic aphasics with left hemisphere lesions. As well as the standard simple reaction time condition, the patients were given a concomitant verbal task, requiring overt articulation while reacting to the visual stimuli. Compared with the control condition, in both aphasic groups the verbal task produced an overall lengthening of latencies, with a significant slowing down of responses to the stimuli located in the right visual half-field. According to these results the verbal concurrent activity appears to involve the left hemisphere as in normal subjects, suggesting that the undamaged regions of the left hemisphere have a role to play in the motor programming of aphasic speech. As a collateral finding, the difference between latencies to stimuli ipsilateral and contralateral to the responding hand—a measure of interhemispheric transmission time—is greatly increased in patients with motor deficits. This is consistent with the view that, in simple visuo-motor reaction time, interhemispheric transfer takes place between anterior regions of the brain.