Mechanisms of action of estrogen and progesterone
Mechanisms of action of estrogen and progesterone
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DOI：
10.1111/j.1749-6632.2002.tb02765.x
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发表时间：
2002-01-01
期刊：
影响因子：
--
通讯作者：
Tsai, SY
中科院分区：
文献类型：
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作者：
DeMayo, FJ;Zhao, BH;Tsai, SY
雌激素和孕激素是类固醇激素，在哺乳动物生殖调节中起着关键作用。这些激素的一个主要作用是调节子宫的发育和功能。这些激素通过调节子宫内特定基因的转录而起作用。这些激素的作用是由它们特定的激素受体介导的。这些受体是核转录因子，其转录调节活性是通过特异性类固醇与这些分子的结合介导的。一旦这些受体与激素结合，它们可以结合到应答基因启动子区域的特定顺式作用序列，并调节这些基因的转录。在转录调控中，这些受体与特定的辅因子相互作用以激活转录机制。第二个基因家族，类固醇受体共激活因子（SRC）家族，已被确定用于调节激素受体的转录活性。到目前为止，已经确定了SRC家族的三个成员。在过去的十年中，基因靶向技术已被用于确定这些受体在生殖和子宫生物学调节中的作用。
Estrogen and progesterone are steroid hormones that play a pivotal role in the regulation of mammalian reproduction. One primary action of these hormones is to regulate the development and function of the uterus. These hormones act by regulating the transcription of specific genes in the uterus. The actions of these hormones are mediated by their specific hormone receptors. These receptors are nuclear transcription factors, whose transcriptional regulatory activity is mediated by the binding of the specific steroid to these molecules. Once these receptors bind hormone, they can bind to specific cis-acting sequences in the promoter region of responsive genes and regulate transcription of these genes. In the regulation of transcription, these receptors interact with specific cofactors to activate the transcriptional machinery. A second gene family, the Steroid Receptor Coactivator (SRC) family, has been identified that serves to modulate the transcriptional activity of the hormone receptors. To date, three members of the SRC family have been identified. During the last decade, gene targeting technology has been used to identify the role of these receptors in the regulation of reproduction and uterine biology.