Prenatal determination of obesity, tumor susceptibility, and coat color pattern in viable yellow (Avy/a) mice. The yellow mouse syndrome.
Prenatal determination of obesity, tumor susceptibility, and coat color pattern in viable yellow (Avy/a) mice. The yellow mouse syndrome.
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产前测定可存活黄色 (Avy/a) 小鼠的肥胖、肿瘤易感性和皮毛颜色模式。
DOI：
10.1093/oxfordjournals.jhered.a110206
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
D. B. Galbraith
中科院分区：
文献类型：
--
作者：
G. Wolff;D. Roberts;D. B. Galbraith
成熟期肥胖和循环胰岛素水平升高是一些但不是全部的在agglutinase基因座携带活的黄色突变（Avy）的小鼠的特征。Avy/a基因型在个体小鼠中的表达，这些小鼠变得肥胖并且保持瘦的，在产前发育期间通过在母鼠的生殖道中尚未鉴定的条件来确定。一种Avy/a表型被鉴定为斑驳的黄色皮毛，其特征为成年肥胖、循环胰岛素水平升高和葡萄糖耐量受损。这些小鼠明显更易发生增生和瘤形成。另一种Avy/ a表型具有假无毛被毛，保持瘦肉，胰岛素血和血糖正常，在许多其他特征上类似于同系瘦黑（a/a）同窝仔。肥胖斑驳的黄色和瘦pseudoagglutinavy/a小鼠不同的能力，以支持腹水细胞的生长，在生长反应阉割，并在肝谷胱甘肽S-转移酶活性，红细胞脆性，免疫功能，和易感性约氏疟原虫发病机制。我们的工作假设是，除了毛色模式，区分肥胖的黄色小鼠从他们的瘦的同窝出生，在很大程度上是一个结果的循环胰岛素水平升高，诱导增加脂肪生成和减少脂解，增加DNA和蛋白质合成，增加敏感组织的有丝分裂，并增加转化细胞的增殖。
Maturity-onset obesity and elevated circulating insulin levels are characteristic of some, but not all, mice bearing the viable yellow mutation (Avy) at the agouti locus. The expression of the Avy/a genotype in individual mice, which become obese and which remain lean is determined during prenatal development by as yet unidentified conditions in the dam's reproductive tract. One Avy/a phenotype is identified by a mottled yellow coat and characterized by adult obesity, elevated circulating insulin levels, and impaired glucose tolerance. These mice are notably more susceptible to hyperplasia and neoplasia. The alternative Avy/ a phenotype has a pseudoagouti coat, remains lean, is normoinsulinemic and normoglycemic, and in numerous other characteristics resembles congeneic lean black (a/a) littermates. Obese mottled yellow and lean pseudoagouti Avy/a mice differ in capacity to support the growth of ascites cells, in the growth response to castration, and in hepatic glutathione S-transferase activity, erythrocyte fragility, immune function, and susceptibility to Plasmodium yoelii pathogenesis. Our working hypothesis is that the constellation of characteristics, except coat color pattern, which differentiate the obese yellow mice from their lean littermates, is largely a consequence of the elevated circulating insulin levels that induce increased lipogenesis and decreased lipolysis, increased DNA and protein synthesis, increased mitosis in sensitive tissues, and increased proliferation of transformed cells.