QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population: the Hisayama study
QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population: the Hisayama study
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DOI：
10.1038/hr.2010.88
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发表时间：
2010-09-01
影响因子：
5.4
通讯作者：
Kiyohara, Yutaka
中科院分区：
文献类型：
--
作者：
Maebuchi, Daisuke;Arima, Hisatomi;Kiyohara, Yutaka
心率校正QT间期(QTC)延长对心血管疾病(CVD)的预测价值仍不确定，特别是在亚洲人群中。本研究的目的是分析日本普通人群中QT间期延长与心血管疾病发展的关系。在随访期内，观察到303例心血管事件。在男性中，随着QTc值的延长，心脑血管疾病的年龄调整发病率上升：QTc值=440ms的亚组分别为10.9、12.1、14.1和37.8‰(趋势P-0.0007)。即使在控制了年龄、高血压、心率、心电图异常、糖尿病、糖耐量减低、空腹血糖受损、体重指数、总和高密度脂蛋白胆固醇、饮酒、吸烟和定期锻炼等其他混杂因素后，最高组的心血管疾病风险也比最低组高3.09倍(95%可信区间，1.82-5.25)。中风和冠心病的结局也观察到了类似的相关性。相比之下，在女性中，QTC水平和心血管事件风险之间没有明显的关联。总而言之，在普通日本男性中，QTC水平延长与心血管疾病的发生有关。QTC间期的测量可能为检测未来心血管事件的高危个体提供额外的信息。高血压研究(2010年)33,916-921；DOI：10.1038/hr.2010.88；2010年6月10日在线发布
Uncertainty remains regarding the value of heart-rate-corrected QT interval (QTc) prolongation on electrocardiogram for predicting cardiovascular disease (CVD), particularly among Asian populations. The objective of the present analysis was to analyze the association of QTc prolongation with the development of CVD in a general Japanese population. During the follow-up period, 303 CVD events were observed. Among men, the age-adjusted incidence rates of CVD rose with prolonged QTc levels: 10.9, 12.1, 14.1 and 37.8 per 1000 person-years for subgroups defined by QTc levels of = 440 ms, respectively (P-0.0007 for trend). The risk of CVD in the highest group was 3.09-fold (95% confidence interval, 1.82-5.25) higher than that in the lowest group even after controlling for other confounding factors: age, hypertension, heart rate, electrocardiogram abnormalities, diabetes, impaired glucose tolerance, impaired fasting glycemia, body mass index, total and high-density lipoprotein cholesterols, alcohol intake, smoking habit and regular exercise. Similar associations were observed for the outcomes of stroke and coronary heart disease. Among women, in contrast, no clear associations were found between QTc levels and the risk of CVD events. In conclusion, prolonged QTc levels were associated with the development of CVD among general Japanese men. Measurement of QTc intervals is likely to provide additional information for the detection of individuals at high risk of future CVD events. Hypertension Research (2010) 33, 916-921; doi: 10.1038/hr.2010.88; published online 10 June 2010