Preparation of Hydantoins by Catalytic Oxidative Carbonylation of α-Amino Amides
Preparation of Hydantoins by Catalytic Oxidative Carbonylation of α-Amino Amides
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DOI：
10.1021/jo9016138
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发表时间：
2009-11-20
影响因子：
3.6
通讯作者：
McElwee-White, Lisa
中科院分区：
文献类型：
--
作者：
Dumbris, Seth M.;Diaz, Delmy J.;McElwee-White, Lisa
以W(CO)(6)为催化剂，I-2为氧化剂，CO为羰基源，DBU为碱，以相应的氨基酰胺为原料，进行氧化催化羰化反应合成海因。仲酰胺为海因提供了很好到很好的产率，随着N-烷基取代基空间体积的增加，产率降低。
Hydantoins can be synthesized from the corresponding amino amides employing oxidative catalytic carbonylation using W(CO)(6) as the catalyst, I-2 as the oxidant, CO as the carbonyl source, and DBU as base. Secondary amides afford the hydantoins in good to excellent yields, which decrease as the steric bulk of the N-alkyl substituent increases.