SUNLIGHT AND AGE-RELATED MACULAR DEGENERATION - THE BEAVER DAM EYE STUDY
SUNLIGHT AND AGE-RELATED MACULAR DEGENERATION - THE BEAVER DAM EYE STUDY
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DOI：
10.1001/archopht.1993.01090040106042
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发表时间：
1993-04-01
影响因子：
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通讯作者：
KLEIN, BEK
中科院分区：
文献类型：
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作者：
CRUICKSHANKS, KJ;KLEIN, R;KLEIN, BEK
客观。-探讨日光暴露与老年性黄斑病变的关系。这在基于人群的比弗坝眼科研究中进行了调查。在这项横断面人群为基础的研究中，问卷调查数据的阳光照射。立体彩色眼底照片进行分级，以确定年龄相关性黄斑病变的存在。1988年至1990年期间，对1987年至1988年期间居住在威斯康星州比弗坝的43至84岁的人进行了检查。光暴露与女性早期年龄相关性黄斑病变无关。在男性中，调整年龄后，夏季户外活动时间与视网膜色素增加相关（比值比[OR]，1.44; 95%置信区间[CI]，1.01至2.04）。戴眼镜与视网膜色素增加呈负相关（OR，0.75; 95%CI，0.58 - 0.97），戴帽子和太阳镜与软性玻璃疣呈负相关（OR，0.61; 95%CI，0.38 - 0.98）。夏季户外休闲时间与渗出性黄斑变性（OR，2.26; 95%CI，1.06 - 4.81）和晚期黄斑病变（OR，2.19; 95%CI，1.12 - 4.25）显著相关。估计环境UV-B暴露和年龄相关性黄斑病变之间没有关联。这些数据表明，暴露于阳光下可能与年龄相关的黄斑病变。然而，这些协会的纵向研究是必要的。
Objective.-To investigate the relationship of sunlight exposure with age-related maculopathy. This was investigated in the population-based Beaver Dam Eye Study.Design.-In this cross-sectional population-based study, questionnaire data about sunlight exposure were obtained. Stereoscopic color fundus photographs were graded to determine the presence of age-related maculopathy.Participants.-People aged 43 through 84 years who resided in Beaver Dam, Wis, between 1987 and 1988 were examined between 1988 and 1990.Results.-Light exposure was not associated with early age-related maculopathy in women. In men, after adjusting for age, the amount of time spent outdoors in summer was associated with increased retinal pigment (odds ratio [OR], 1.44; 95% confidence interval [CI], 1.01 to 2.04). Wearing eyeglasses was inversely associated with increased retinal pigment (OR, 0.75; 95% CI, 0.58 to 0.97), and the use of hats and sunglasses was inversely associated with soft indistinct drusen (OR, 0.61; 95% CI, 0.38 to 0.98). The amount of leisure time spent outdoors in summer was significantly associated with exudative macular degeneration (OR, 2.26; 95% CI, 1.06 to 4.81) and late maculopathy (OR, 2.19; 95% CI, 1.12 to 4.25). There were no associations between estimated ambient UV-B exposure and age-related maculopathy.Conclusions.-These data suggest that exposure to sunlight may be associated with age-related maculopathy. However, longitudinal studies of these associations are needed.