VGR-1, A MAMMALIAN GENE RELATED TO XENOPUS VG-1, IS A MEMBER OF THE TRANSFORMING GROWTH FACTOR-BETA GENE SUPERFAMILY
VGR-1, A MAMMALIAN GENE RELATED TO XENOPUS VG-1, IS A MEMBER OF THE TRANSFORMING GROWTH FACTOR-BETA GENE SUPERFAMILY
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DOI：
10.1073/pnas.86.12.4554
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发表时间：
1989-06-01
影响因子：
11.1
通讯作者：
DERYNCK, R
中科院分区：
文献类型：
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作者：
LYONS, K;GRAYCAR, JL;DERYNCK, R
转化生长因子β。非洲爪蟾 Vg-1 和果蝇 decapentaplegic (DPP) 基因的 (TGF-β) 相关产物与胚胎发生过程中生长和分化的控制有关。我们分离出了小鼠 cDNA，Vgr-1，它编码与爪蟾 Vg-1 结构相关的多肽。序列比较表明Vgr-1蛋白属于TGF-β内的DPP样基因产物家族。超家族。在不同发育阶段分离的胚胎和组织中测定了 Vgr-1 RNA 的水平。在许多组织和响应视黄酸和 cAMP 分化为内胚层的 F9 畸胎癌细胞中，3.5 KB 的 mRNA 在整个发育过程中增加并进入成年期。氨基酸同源性和表达模式表明，与 DPP 基因产物一样，Vgr-1 在发育的各个阶段发挥作用。
The transforming growth factor .beta. (TGF-.beta.)-related products of the Xenopus Vg-1 and Drosophila decapentaplegic (DPP) genes have been implicated in the control of growth and differentiation during embryogenesis. We have isolated a mouse cDNA, Vgr-1, that encodes a polypeptide structurally related to Xenopus Vg-1. Sequence comparisons indicate that the Vgr-1 protein belongs to a family of DPP-like gene products within the TGF-.beta. superfamily. The levels of Vgr-1 RNA were determined in embryos and tissues isolated at various stages of development. A 3.5-kilobase mRNA increases throughout development and into adulthood in many tissues and in F9 teratocarcinoma cells differentiating into endoderm in response to retinoic acid and cAMP. The amino acid homologies and patterns of expression suggest that, like the DPP gene product, Vgr-1 plays a role at various stages of development.