Accelerated DNA methylation age: Associations with PTSD and neural integrity.
Accelerated DNA methylation age: Associations with PTSD and neural integrity.
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DOI：
10.1016/j.psyneuen.2015.09.020
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发表时间：
2016-01
影响因子：
3.7
通讯作者：
Miller MW
中科院分区：
文献类型：
--
作者：
Wolf EJ;Logue MW;Hayes JP;Sadeh N;Schichman SA;Stone A;Salat DH;Milberg W;McGlinchey R;Miller MW
越来越多的证据表明，创伤后应激障碍（PTSD）可能会加速细胞衰老，导致过早发病和神经认知能力下降。本研究评估了创伤后应激障碍和DNA甲基化（DNAm）年龄之间的关联，使用最近开发的细胞年龄算法。这些估计值反映了超过实际年龄时的加速老化。我们还检查了加速的细胞年龄是否表现为神经完整性的退化，通过扩散张量成像进行索引。在281名参加过伊拉克和阿富汗战争的男女退伍军人中，DNA年龄与实足年龄密切相关（rs ~.88）。终生PTSD的严重程度与汉纳姆DNA年龄估计值相关（β = 0.13，p= 0.032）。年龄越大的DNA m与胼胝体前部的完整性降低有关（β =-0.17，p= .009），并通过该区域间接与较差的工作记忆表现有关（间接β =-0.05，p= .029）。Horvath DNA年龄估计与PTSD或神经完整性无关。结果为DNA m中与创伤后应激障碍相关的加速老化提供了新的支持，并扩展了已知DNA m年龄与神经完整性和认知领域相关的证据基础。
Accumulating evidence suggests that post traumatic stress disorder (PTSD) may accelerate cellular aging and lead to premature morbidity and neurocognitive decline. This study evaluated associations between PTSD and DNA methylation (DNAm) age using recently developed algorithms of cellular age by and. These estimates reflect accelerated aging when they exceed chronological age. We also examined if accelerated cellular age manifested in degraded neural integrity, indexed via diffusion tensor imaging. Among 281 male and female veterans of the conflicts in Iraq and Afghanistan, DNAm age was strongly related to chronological age (rs ~.88). Lifetime PTSD severity was associated with Hannum DNAm age estimates residualized for chronological age (β = .13, p= .032). Advanced DNAm age was associated with reduced integrity in the genu of the corpus callosum (β = −.17, p= .009) and indirectly linked to poorer working memory performance via this region (indirect β = − .05, p= .029). Horvath DNAm age estimates were not associated with PTSD or neural integrity. Results provide novel support for PTSD-related accelerated aging in DNAm and extend the evidence base of known DNAm age correlates to the domains of neural integrity and cognition.