Decrease of theta response in euthymic bipolar patients during an oddball paradigm
Decrease of theta response in euthymic bipolar patients during an oddball paradigm
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DOI：
10.1007/s11571-012-9228-7
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发表时间：
2013-06-01
影响因子：
3.7
通讯作者：
Basar, E.
中科院分区：
文献类型：
--
作者：
Atagun, M. I.;Guntekin, B.;Basar, E.
θ振荡与认知功能有关，反映了额叶和内侧颞叶结构整合到连贯的神经认知网络中的功能。本研究评估了无药物治疗、情绪正常的双相情感障碍患者在听觉oddball范式下的事件相关θ波振荡。纳入22例DSM-IV正常胸腺双相I型（n = 19）和II型（n = 3）患者和22例健康受试者。患者至少6个月保持正常情绪，至少2周不服用精神药物。在30个电极部位记录EEG。采用听觉oddball范式和感觉刺激。在两个不同的θ频带（4-6 Hz，6-8 Hz）中使用自适应滤波分析事件相关振荡。在健康受试者中，对目标、非目标和感觉刺激的慢θ（4-6 Hz）反应显著高于正常胸腺患者（p < 0.05）。在仅靶刺激时，健康受试者的快θ（6-8 Hz）反应显著高于正常胸腺患者（p < 0.05）。听觉处理过程中θ振荡的减少为双相情感障碍相关网络的激活缺陷提供了强有力的定量证据。快θ反应与认知功能相关，而慢θ反应与感觉过程的相关性大于认知过程。
Theta oscillations are related to cognitive functions and reflect functional integration of frontal and medial temporal structures into coherent neurocognitive networks. This study assessed event-related theta oscillations in medication-free, euthymic patients with bipolar disorder upon auditory oddball paradigm. Twenty-two DSM-IV euthymic bipolar I (n = 19) and II (n = 3) patients and twenty-two healthy subjects were included. Patients were euthymic for at least 6 months, and psychotropic-free for at least 2 weeks. EEG was recorded at 30 electrode sites. Auditory oddball paradigm and sensory stimuli were used. Event-related Oscillations were analyzed using adaptive filtering in two different theta frequency bands (4-6 Hz, 6-8 Hz). In healthy subjects, slow theta (4-6 Hz) responses were significantly higher than those of euthymic patients upon target, non-target and sensory stimuli (p < 0.05). Fast theta (6-8 Hz) responses of healthy subjects were significantly higher than those of euthymic patients upon target-only stimuli (p < 0.05). Reduced theta oscillations during auditory processing provide strong quantitative evidence of activation deficits in related networks in bipolar disorder. Fast theta responses are related to cognitive functions, whereas slow theta responses are related to sensory processes more than cognitive processes.