Marine Isonitriles and Their Related Compounds.
Marine Isonitriles and Their Related Compounds.
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DOI：
10.3390/md14010016
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发表时间：
2016-01-14
期刊：
影响因子：
5.4
通讯作者：
Opatz T
中科院分区：
文献类型：
--
作者：
Emsermann J;Kauhl U;Opatz T
海洋异腈代表了最大的一组带有显着异氰化物部分的天然产物。它们与源自相同生物合成途径的海洋异硫氰酸酯和甲酰胺一起提供了多种生物活性，尽管它们具有奇异的性质，但它们可能构成药物开发的潜在先导结构。除其他生物活性外，几种海洋异腈还具有抗疟疾、抗结核、防污和抗疟原虫作用。与大部分源自α-氨基酸的陆地异腈不同，绝大多数海洋异腈均源自萜类化合物。将概述所有已知的海洋异腈及其同系物，并讨论它们的生物和化学方面。
Marine isonitriles represent the largest group of natural products carrying the remarkable isocyanide moiety. Together with marine isothiocyanates and formamides, which originate from the same biosynthetic pathways, they offer diverse biological activities and in spite of their exotic nature they may constitute potential lead structures for pharmaceutical development. Among other biological activities, several marine isonitriles show antimalarial, antitubercular, antifouling and antiplasmodial effects. In contrast to terrestrial isonitriles, which are mostly derived from α-amino acids, the vast majority of marine representatives are of terpenoid origin. An overview of all known marine isonitriles and their congeners will be given and their biological and chemical aspects will be discussed.