Striatal dopamine transporter binding assessed by [I-123]IPT and single photon emission computed tomography in patients with early Parkinson's disease: implications for a preclinical diagnosis.
Striatal dopamine transporter binding assessed by [I-123]IPT and single photon emission computed tomography in patients with early Parkinson's disease: implications for a preclinical diagnosis.
复制标题
通过 [I-123]IPT 和单光子发射计算机断层扫描评估早期帕金森病患者的纹状体多巴胺转运蛋白结合：对临床前诊断的影响。
DOI：
10.1001/archneur.57.2.205
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发表时间：
2000
影响因子：
--
通讯作者：
K. Tatsch
中科院分区：
文献类型：
--
作者：
Johannes Schwarz;R. Linke;Martina Kerner;P. Mozley;C. Trenkwalder;T. Gasser;K. Tatsch
背景
特异性结合多巴胺转运蛋白可以作为一种工具，以检测早期损失的黑质纹状体多巴胺能神经元在帕金森病患者。
目的
使用可卡因类似物[I-123]N-（3-碘丙烯-2-基）-2 β-甲氧羰基-3 β-（4-氯苯基）托烷（[I-123]IPT）和单光子发射计算机断层扫描测定纹状体多巴胺转运蛋白结合。
患者和方法
我们研究了9名对照受试者（平均年龄，58岁;范围，41-69岁）和28名早期帕金森病患者（Hoehn和Yahr I期[n = 14]和II期[n = 14] [症状持续时间，<5年];平均年龄，55.5岁;范围，36-71岁）。注射120 - 150 MBq放射性[I-123]IPT后90分钟进行单光子发射计算机断层扫描。
结果
特异性纹状体[I-123] IPT结合（平均值+/- SD）在早期帕金森病患者中显著降低（同侧纹状体：4.09+/-0.97;范围：2.46-6.40;对侧纹状体：3.32+/-0.76;范围：1.80-5.13）（左纹状体：7.28 ± 0.94;范围：5.78-8.81;右纹状体：7.41 ± 1.28;范围：5.58-9.44）。与Hoehn-Yahr I期患者（同侧纹状体：4.72+/-0.75;对侧纹状体：3.69 +/-0.61）相比，Hoehn-Yahr II期患者（同侧纹状体：3.47+/-0.75;对侧纹状体：2.96 +/-0.73）的IPT结合率（平均值+/- SD）显著降低（P<0.001）。与对照组的右侧或左侧纹状体相比，Hoehn和Yahr I期患者的同侧纹状体显示出平均+/-SD的IPT结合显着减少（同侧纹状体：4.72+/-0.75）（P<.001）。仅1例患者的IPT与同侧纹状体的结合（比率，6.40）高于对照受试者纹状体中观察到的最低值（比率，5.58）。
结论
使用[I-123] IPT和单光子发射计算机断层扫描证实早期帕金森病患者多巴胺转运蛋白结合减少。在Hoehn和Yahr I期患者的同侧纹状体中已经观察到IPT结合显著降低，这证明了该方法检测临床前疾病的潜力。
BACKGROUND
Specific binding to dopamine transporters may serve as a tool to detect early loss of nigrostriatal dopaminergic neurons in patients with Parkinson's disease.
OBJECTIVE
To determine striatal dopamine transporter binding using the cocaine analogue [I-123]N-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(4-chl orophenyl) tropane ([I-123]IPT) and single photon emission computed tomography.
PATIENTS AND METHODS
We studied 9 control subjects (mean age, 58 years; range, 41-69 years) and 28 patients with early Parkinson's disease (Hoehn and Yahr stages I [n = 14] and II [n = 14] [symptom duration, <5 years]; mean age, 55.5 years; range, 36-71 years). Single photon emission computed tomography was performed 90 minutes after injection of 120 to 150 MBq of radioactive [I-123]IPT.
RESULTS
Specific striatal [I-123] IPT binding (mean +/- SD) was significantly reduced in patients with early Parkinson's disease (ipsilateral striatum: 4.09+/-0.97; range, 2.46-6.40; contralateral striatum: 3.32+/-0.76; range, 1.80-5.13) compared with controls (left striatum: 7.28+/-0.94; range, 5.78-8.81; right striatum: 7.41+/-1.28; range, 5.58-9.44). IPT binding ratios (mean +/- SD) were significantly lower in patients with Hoehn and Yahr stage II (ipsilateral striatum: 3.47+/-0.75; contralateral striatum: 2.96+/-0.73) compared with those with Hoehn and Yahr stage I (ipsilateral striatum: 4.72+/-0.75; contralateral striatum: 3.69+/-0.61) (P<.001). The ipsilateral striatum of patients with Hoehn and Yahr stage I showed a significant mean+/-SD reduction of IPT binding (ipsilateral striatum: 4.72+/-0.75) compared with either right or left striatum of controls (P<.001). Only in 1 patient was IPT binding to the ipsilateral striatum (ratio, 6.40) higher than the lowest value observed in the striatum of a control subject (ratio, 5.58).
CONCLUSIONS
Use of [I-123] IPT and single photon emission computed tomography demonstrates a reduction of dopamine transporter binding in patients with early Parkinson's disease. Significantly reduced IPT binding already observed in the ipsilateral striatum of patients with Hoehn and Yahr stage I demonstrates the potential of this method to detect preclinical disease.
CNS 多巴胺转运蛋白的 Iodine-123-IPT SPECT 成像：正常衰老对纹状体摄取值的非线性影响。
DOI：
--
发表时间：
1996
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Mozley,PD;Kim,HJ;Gur,RC;Tatsch,K;Muenz,LR;McElgin,WT;Kung,MP;Mu,M;Myers,AM;Kung,HF
通讯作者：
Kung,HF
碘 123 标记托烷的剂量测定对多巴胺转运蛋白进行成像。
DOI：
--
发表时间：
1996
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Mozley,PD;Stubbs,JB;Kim,HJ;McElgin,W;Kung,MP;Meegalla,S;Kung,HF
通讯作者：
Kung,HF