Comprehensive strategy for chiral separations using sulfated cyclodextrins in capillary electrophoresis.
Comprehensive strategy for chiral separations using sulfated cyclodextrins in capillary electrophoresis.
复制标题
DOI：
10.1002/chir.10285
复制
发表时间：
2003
期刊：
影响因子：
2
通讯作者：
C. E. Evans;A. Stalcup
中科院分区：
文献类型：
--
作者：
C. E. Evans;A. Stalcup
本文综述了硫酸环糊精在手性分析物毛细管电泳（CE）分离中的新作用。自1995年作为CE的对映选择性剂引入以来，这些阴离子添加剂继续显示出显著的应用普遍性。使用这种方法成功分离的广谱手性化合物包括酸性、碱性、中性和两性离子。这些令人印象深刻的分析物结构来自于越来越多样化的化合物类别，包括药物、植物提取物、生物标志物、除草剂、生物碱、杀菌剂和金属离子。此外，文献报告强调了实现成功分离所需的最小优化。基于这些发现，硫酸环糊精似乎非常适合于开发一种更普遍、更全面的手性化合物分离策略。本文从硫酸环糊精的结构和迁移特性开始，通过应用来突出该技术的分离能力，并以实用的综合分离策略结束。
This review focuses on the emerging role of sulfated cyclodextrins in the capillary electrophoretic (CE) separation of chiral analytes. Since being introduced as enantioselective agents for CE in 1995, these anionic additives have continued to demonstrate remarkable application universality. The broad spectrum of chiral compounds successfully separated using this approach includes acidic, basic, neutral, and zwitterionic species. This impressive array of analyte structures is derived from a growing diversity of compound classes including pharmaceuticals, plant extracts, biomarkers, herbicides, alkaloids, fungicides, and metal ions. Moreover, literature reports highlight the minimal optimization required to achieve a successful separation. Based on these findings, sulfated cyclodextrins appear to be well suited for the development of a more universal, comprehensive separation strategy for chiral compounds. This review explores this proposition by beginning with the structure and migration properties of sulfated cyclodextrins, using applications to highlight the separating power of this technique and ending with a pragmatic, comprehensive separation strategy.