KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma.
KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma.
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胰腺导管腺癌中 KRAS 相关非编码 RNA
DOI：
10.1016/j.cdtm.2016.11.012
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发表时间：
2016-12
影响因子：
--
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Yu SN;Ma YH;Zhao WG;Jin XL;Yang HY;Liu PP;Chen J
胰腺导管腺癌（PDAC）是一种预后不良的致死性疾病。然而，在疾病的早期阶段进行根治性切除可以大大提高生存率，突出了早期筛查和检测的重要性。对非编码RNA（主要是microRNA（miRNA）和长链非编码RNA（lncRNA））的研究为KRAS驱动的PDAC的早期检测策略提供了重要的见解。在这里，我们总结了我们的研究和审查目前的研究报告调查KRAS相关的miRNA和lncRNA，强调其异常表达，机制，致癌作用，预后和预测能力的PDAC。
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a poor overall prognosis. However, curative resection during the early stages of the disease can greatly improve survival rates, highlighting the importance of early screening and detection. Studies of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), provide important insights into strategies for the early detection of KRAS-driven PDAC. Here, we summarize our studies and review current reports on research investigating KRAS-related miRNAs and lncRNAs, emphasizing their aberrant expression, mechanisms, carcinogenic effects, and prognostic and predictive capacities in PDAC.