STANDARDIZED UPTAKE VALUES OF NORMAL-TISSUES AT PET WITH 2-[FLUORINE-L8]-FLUORO-2-DEOXY-D-GLUCOSE - VARIATIONS WITH BODY-WEIGHT AND A METHOD FOR CORRECTION
STANDARDIZED UPTAKE VALUES OF NORMAL-TISSUES AT PET WITH 2-[FLUORINE-L8]-FLUORO-2-DEOXY-D-GLUCOSE - VARIATIONS WITH BODY-WEIGHT AND A METHOD FOR CORRECTION
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DOI：
10.1148/radiology.189.3.8234714
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发表时间：
1993-12-01
期刊：
影响因子：
19.7
通讯作者：
WAHL, RL
中科院分区：
文献类型：
--
作者：
ZASADNY, KR;WAHL, RL
目的：研究正电子发射断层扫描（PET）测定正常组织中标准化摄取值（SUVs）与体重的关系。材料和方法：对28名新诊断未经治疗的原发性乳腺癌的非糖尿病女性进行了suv检测。体重从45公斤到107公斤不等。注射2-[氟-18]-氟-2-脱氧-d -葡萄糖（FDG）后50-60分钟用PET成像测定肺、肝、骨髓、脾脏、血液和正常乳腺的suv。结果：血（r = .75, P = .000004）、肝（r = .72, P = .000081）、脾（r = .57, P = .033）中SUV与体重呈正相关，均具有较高的F-18活性。在体重较重的患者中，用于正常组织的suv是体重较轻患者的两倍。根据预测瘦体质量（SUV- lean）计算SUV消除了SUV对血液的体重依赖性（r = 0.26, P = 0.18），降低了SUV对其他组织的体重依赖性。结论：SUV- lean是一种与体重无关的PET血FDG积累指标，可能比SUV更适合用于量化肿瘤中F-18的活性。
PURPOSE: To study the relationship between standardized uptake values (SUVs) in normal tissues and body weight determined with positron emission tomography (PET).MATERIALS AND METHODS: SUVs were determined in 28 nondiabetic women with newly diagnosed untreated primary breast cancers. Body weights ranged from 45 to 107 kg. SUVs for lung, liver, marrow, spleen, blood, and normal breast were determined from images obtained with PET 50-60 minutes after injection of 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG).RESULTS: There was a positive correlation between SUV and body weight for blood, (r = .75, P = .000004), liver (r = .72, P = .000081), and spleen (r = .57, P = .033), all of which had substantial F-18 activity. In heavy patients, SUVs fo r those normal tissues were up to twice those of lighter patients. Calculating SUV on the basis of predicted lean body mass (SUV-Lean) eliminated the weight dependence of the SUV for blood (r =.26, P =.18) and reduced weight dependence in other tissues.CONCLUSION: SUV-Lean is a weight-independent index for blood FDG accumulation at PET and may be more appropriate than SUV for quantifying F-18 activity in tumors.