The relationship of retinal vessel diameter to changes in diabetic nephropathy structural variables in patients with type 1 diabetes.
The relationship of retinal vessel diameter to changes in diabetic nephropathy structural variables in patients with type 1 diabetes.
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DOI：
10.1007/s00125-010-1763-3
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发表时间：
2010-08
期刊：
影响因子：
8.2
通讯作者：
Mauer, M.
中科院分区：
文献类型：
--
作者：
Klein, R.;Knudtson, M. D.;Klein, B. E. K.;Zinman, B.;Gardiner, R.;Suissa, S.;Sinaiko, A. R.;Donnelly, S. M.;Goodyer, P.;Strand, T.;Mauer, M.
关键词：
探讨1型糖尿病（T1DM）患者视网膜血管直径是否与亚临床解剖和功能性糖尿病肾病指标的变化相关。T1DM患者在基线和5年随访时均有可分级的眼底照片和肾活检数据（n=234）。在基线和随访时测量视网膜小动脉和静脉直径。计算视网膜中央小动脉（CRAE）和视网膜中央小静脉当量（CRVE）。基线和5年随访肾脏结构参数（如系膜分数体积和肾小球基底膜宽度（GBMW）以及系膜基质分数体积和GBMW复合肾小球病变指数）通过经皮肾活检标本的隐性电子显微镜形态分析进行评估。在控制其他协变量的同时，基线CRAE与5年期间肾小球病变指数的变化呈正相关。cre的变化与系膜基质体积分数的变化呈负相关，而CRVE的变化与5年期间皮质间质体积分数[Vv(Int/cortex)]的变化直接相关。基线cre或CRVE或这些直径的变化与其他肾脏解剖或功能终点的变化无关。在我们的研究中，独立于其他因素，基线CRAE与肾小球病变指数的变化相关，肾小球病变指数是衡量系膜和GBM中细胞外基质积累的综合指标，而CRAE的变窄与系膜基质积累有关。CRVE的变化与Vv（Int/cortex）的变化有关，Vv是衡量T1DM患者间质扩张的指标。
To examine whether retinal vessel diameter in persons with type 1 diabetes mellitus (T1DM) is associated with changes in subclinical anatomic and functional diabetic nephropathy indicators. Persons with T1DM had both gradable fundus photographs and renal biopsy data at baseline and 5-year follow-up (n=234). Retinal arteriolar and venular diameters were measured at baseline and follow-up. Central retinal arteriolar (CRAE) and central retinal venule equivalent (CRVE) were computed. Baseline and 5-year follow-up renal structural parameters (e.g., mesangial fractional volume and glomerular basement membrane width (GBMW) and the mesangial matrix fractional volume and GBMW composite glomerulopathy index) were assessed by masked electron microscopic morphometric analyses from percutaneous renal biopsy specimens. While controlling for other covariates, baseline CRAE was positively associated with change in the glomerulopathy index over the 5 year period. Change in CRAE was inversely related to a change in mesangial matrix fractional volume while change in CRVE was directly related to change in the volume fractions of cortex which was interstitium [Vv(Int/cortex)] over the 5-year period. Baseline CRAE or CRVE or changes in these diameters were not related to changes in other renal anatomic or functional endpoints. In our study, independent of other factors, baseline CRAE correlated with changes in glomerulopathy index, a composite measure of extracellular matrix accumulation in the mesangium and GBM, while a narrowing of the CRAE was related to mesangial matrix accumulation. Changes in CRVE were related to changes in Vv(Int/cortex), a measure of interstitial expansion in persons with T1DM.
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影响因子：
19.6
作者：
ELLIS, EN;STEFFES, MW;MAUER, SM
通讯作者：
MAUER, SM
影响因子：
6.1
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Donnelly, Sandra;Goodyer, Paul;Mauer, Michael
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Mauer, Michael
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作者：
Katz, A;Caramori, MLA;Mauer, M
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Mauer, M
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作者：
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作者：
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通讯作者：
Klein, BEK