Matrix proteases, green tea, and St. John's wort: Biomedical research catches up with folk medicine
Matrix proteases, green tea, and St. John's wort: Biomedical research catches up with folk medicine
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DOI：
10.1016/j.cca.2007.02.022
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发表时间：
2007-05-01
影响因子：
5
通讯作者：
Garbisa, Spiridione
中科院分区：
文献类型：
--
作者：
Dell'Aica, Isabella;Caniato, Rosy;Garbisa, Spiridione
背景：一些参与细胞外基质降解的蛋白酶不仅有助于克服组织障碍，使血细胞正常外渗，而且还有助于炎症、血管生成和肿瘤侵袭等病理过程。阻断这些酶的可能性导致了合成抑制剂的开发，尽管由于相当大的副作用，临床试验令人失望。然而，早在酶第一次被分离出来之前，这些相同的病症就已经在以植物为基础的民间疗法中得到治疗，今天科学正在筛选它们的有益效果。现状：我们介绍了两种蔬菜成分作为蛋白酶抑制剂的研究。第一种，（-）表没食子儿茶素-3-没食子酸酯-来自绿茶，已被证明是抑制明胶酶MMP-2和MMP-9的好武器，但它是白细胞弹性酶（LE）活性的更好抑制剂；在体内，它能阻断炎症、血管生成和肿瘤侵袭。第二种，hyperperin -来自金丝桃，抑制le触发的MMP-9激活、PMN趋化性和化学侵袭、PMN触发的血管生成和炎症引发的肺纤维化；它还能抑制肿瘤细胞中MMP-2的表达，从而抑制肿瘤细胞的侵袭和转移。结论：现代研究清楚地证明了两种长期使用的植物界盟友的有益作用的流行病学和历史证据，并进一步阐明了机制关键。(c) 2007 Elsevier B.V.版权所有
Background: Some proteases involved in extracellular matrix degradation are instrumental not only in overcoming tissue barriers to allow normal extravasation of hematic cells, but also in facilitating pathological processes such as inflammation, angiogenesis and tumor invasion. The possibility of blocking these enzymes has led to the development of synthetic inhibitors, though clinical trials have been disappointing owing to considerable side effects. However, long before enzymes were first isolated, these same pathologies were being treated in plant-based folk remedies, and today science is screening them for their reputed beneficial effects.State of the art: We present studies of 2 vegetable components as protease inhibitors. The first, (-)epigallocatechin-3-gallate - from green tea, has proved a good weapon for inhibiting gelatinases MMP-2 and MMP-9, but an even better inhibitor of leukocyte elastase (LE) activity; in vivo it blocks inflammation, angiogenesis and tumor invasion. The second, hyperforin - from Hypericum sp, inhibits LE-triggered activation of MMP-9, PMN chemotaxis and chemoinvasion, PMN-triggered angiogenesis, and inflammation-triggered pulmonary fibrosis; it also represses tumor-cell expression of MMP-2, thereby restraining invasion and metastasis.Conclusion: Modem research clearly vindicates epidemiological and historical evidence of the beneficial effects of two long-used allies from the plant kingdom, going a step beyond by shedding light on mechanistic keys. (c) 2007 Elsevier B.V. All rights reserved.