The impact of micronutrient deficiency on pregnancy complications and development origin of health and disease
The impact of micronutrient deficiency on pregnancy complications and development origin of health and disease
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DOI：
10.1111/jog.14770
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发表时间：
2021-03-29
影响因子：
1.6
通讯作者：
Kumagai, Asako
中科院分区：
文献类型：
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作者：
Kanasaki, Keizo;Kumagai, Asako
由于以大量摄入加工食品为特征的西式饮食的传播，日本各年龄和性别的人口中微量营养素（维生素和矿物质）缺乏症正在增加。在怀孕期间，对微量营养素需求的增加使孕妇面临更大的微量营养素缺乏风险。有些微量营养素比较有名，因此建议育龄妇女服用叶酸补充剂，以预防神经管缺损。然而，叶酸在整个怀孕过程中对胎儿生长和预防妊娠并发症也很重要，孕妇在怀孕和哺乳期间应该继续补充叶酸，这一点通常并不为人所知。微量营养素的种类和补充时间都是维持正常妊娠的重要因素。这篇综述的重点是日本孕妇普遍缺乏的四种微量营养素：叶酸、维生素B12、维生素D、钙和镁。本文描述了与上述微量营养素缺陷相关的同型半胱氨酸积累的有害影响及其与儿茶酚-o-甲基转移酶不足的联系。我们还从单碳代谢的角度讨论了妊娠并发症的可能分子机制和微量营养素缺乏的健康和疾病的发展起源。
Due to the spread of the western style diet, which is characterized by high intake of processed food, micronutrients (vitamins and minerals) deficiency is increasing in the Japanese population of all ages and genders. During pregnancy, the elevated demand for micronutrients put pregnant women at even higher risk of micronutrients deficiency. Some micronutrients are relatively famous such that women with reproductive age are recommended to take folic acid supplementation for the prevention of neural tube defect. However, it is not generally known that folate is also important for fetal growth throughout the pregnancy course and for prevention of pregnancy complications, and that pregnant women should continue to take supplementation during pregnancy and lactation. The types of micronutrients and the duration of supplementation are both important factors to maintain normal pregnancies. This review focused on four micronutrients that are commonly deficient in Japanese pregnant women, folate, vitamin B12, vitamin D, calcium, and magnesium. The detrimental effects of homocysteine accumulation associated with the above micronutrient defects and its link to catechol-o-methyltransferase insufficiency are described. We also discussed possible molecular mechanisms of pregnancy complications and the development origin of health and disease (DOHaD) regarding micronutrient deficiencies from the point of view of one carbon metabolism.